6-Cyclopropyl-4,5-difluoro-3-hydroxy-9-oxo-6,9-dihydro-1H-pyrrolo[2,3-f]quinoline-2,8-dicarboxylic acid diethyl ester | 142665-87-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Cyclopropyl-4,5-difluoro-3-hydroxy-9-oxo-6,9-dihydro-1H-pyrrolo[2,3-f]quinoline-2,8-dicarboxylic acid diethyl ester
• 英文别名: diethyl 6-cyclopropyl-4,5-difluoro-3-hydroxy-9-oxo-1H-pyrrolo[2,3-f]quinoline-2,8-dicarboxylate
• CAS: 142665-87-0
• 化学式: C₂₀H₁₈F₂N₂O₆
• 分子量: 420.37
• InChiKey: DZEBGATVMAOYJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  6-Cyclopropyl-4,5-difluoro-3-hydroxy-9-oxo-6,9-dihydro-1H-pyrrolo[2,3-f]quinoline-2,8-dicarboxylic acid diethyl ester 在 硫酸 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以94%的产率得到6-Cyclopropyl-4,5-difluoro-3-hydroxy-9-oxo-6,9-dihydro-1H-pyrrolo[2,3-f]quinoline-2,8-dicarboxylic acid 2-ethyl ester
  参考文献：
  名称：

  Pyrroloquinolones and pyrazoloquinolones as potential antibacterial agents. Synthesis and antibacterial activity

  摘要：

  Diethyl 1-cyclopropyl-5,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3,6-dicarboxylate as a key-intermediate was synthesized via the Dieckmann reaction. The reaction of 4 with nucleophiles proceeded regioselectively at C-5. Facile cyclization between the C-5 and C-6 side chains of the resulting products gave novel pyrroloquinolones 10 and 12 and pyrazoloquinolones 15. They were converted into a series of cyclic amino-substituted pyrroloquinolones 17-21 and pyrazoloquinolones 22-24, and their in vitro antibacterial activities were tested. 1H-Pyrrolo[2,3-f]quinolone 17a and 2H-pyrrolo[3,4-f]quinolone 21a exhibited a potent in vitro antibacterial activity.

  DOI：

  10.1016/s0223-5234(97)86177-6
• 作为产物：
  描述：

  diethyl 2,4,5,6-tetrafluoroisophthalate 在 potassium tert-butylate 、 溴 、 碳酸氢钠 、 potassium carbonate 作用下， 以 四氢呋喃 、 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 、 甲苯 、 叔丁醇 为溶剂， 反应 5.83h， 生成 6-Cyclopropyl-4,5-difluoro-3-hydroxy-9-oxo-6,9-dihydro-1H-pyrrolo[2,3-f]quinoline-2,8-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Pyrroloquinolones and pyrazoloquinolones as potential antibacterial agents. Synthesis and antibacterial activity

  摘要：

  Diethyl 1-cyclopropyl-5,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3,6-dicarboxylate as a key-intermediate was synthesized via the Dieckmann reaction. The reaction of 4 with nucleophiles proceeded regioselectively at C-5. Facile cyclization between the C-5 and C-6 side chains of the resulting products gave novel pyrroloquinolones 10 and 12 and pyrazoloquinolones 15. They were converted into a series of cyclic amino-substituted pyrroloquinolones 17-21 and pyrazoloquinolones 22-24, and their in vitro antibacterial activities were tested. 1H-Pyrrolo[2,3-f]quinolone 17a and 2H-pyrrolo[3,4-f]quinolone 21a exhibited a potent in vitro antibacterial activity.

  DOI：

  10.1016/s0223-5234(97)86177-6