methyl bis[[(1R,4S,5R,8S,9S,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]methyl] phosphate | 1140906-06-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methyl bis[[(1R,4S,5R,8S,9S,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]methyl] phosphate
• CAS: 1140906-06-4
• 化学式: C₃₃H₅₃O₁₂P
• 分子量: 672.75
• InChiKey: ZVAJAAWKSKUNFE-IFLTYWDRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  46
• 可旋转键数：
  7
• 环数：
  10.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  119
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  10β-(hydroxymethyl)-9-epi-deoxoartemisinin 、 二氯磷酸甲酯 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 以32%的产率得到methyl bis[[(1R,4S,5R,8S,9S,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]methyl] phosphate
  参考文献：
  名称：

  Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells

  摘要：

  A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity ( as low as 30 pM) versus Plasmodium falciparum and in vitro anticancer activity in the micromolar to nanomolar range versus HL-60 cell lines. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.12.017

文献信息

• Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells
  作者：James Chadwick、Amy E. Mercer、B. Kevin Park、Richard Cosstick、Paul M. O’Neill

  DOI：10.1016/j.bmc.2008.12.017

  日期：2009.2

  A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity ( as low as 30 pM) versus Plasmodium falciparum and in vitro anticancer activity in the micromolar to nanomolar range versus HL-60 cell lines. (c) 2009 Elsevier Ltd. All rights reserved.