2,5-anhydro-1-azido-3,4-di-O-tert-butyldimethylsilyl-1-deoxy-D-mannitol | 949582-41-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-anhydro-1-azido-3,4-di-O-tert-butyldimethylsilyl-1-deoxy-D-mannitol
• CAS: 949582-41-6
• 化学式: C₁₈H₃₉N₃O₄Si₂
• 分子量: 417.696
• InChiKey: JELBFIMZYOTXHJ-KLHDSHLOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.84
• 重原子数：
  27.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  96.68
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2,5-anhydro-1-azido-3,4-di-O-tert-butyldimethylsilyl-1-deoxy-D-mannitol 在 palladium on activated charcoal 六甲基磷酰三胺 、 正丁基锂 、 氢气 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 14.0h， 生成 (2R,3S,4S,5R)-2-((bis(cyclohexylmethyl)amino)methyl)-5-(2-((2R,3S,4S,5R)-5-((bis(cyclohexylmethyl)amino)methyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)ethyl)-tetrahydrofuran-3,4-diol
  参考文献：
  名称：

  Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis

  摘要：

  Herein we report the Synthesis of symmetrical C-linked and pseudo-symmetrical O-linked disaccharides structurally related to Araf motifs present in the cell wall of MTB. Their activity in a competition-based arabinosyltransferase assay using [C-14]-DPA as the glycosyl donor is also presented. In addition, in vitro inhibitory activity for the disaccharides was determined in a colorimetric broth microdilution assay system against MTB H37Ra and Mycobacterium avium. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.099
• 作为产物：
  描述：

  2,5-anhydro-1-azido-1-deoxy-D-mannitol 在 咪唑 、 三氟乙酸 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 2,5-anhydro-1-azido-3,4-di-O-tert-butyldimethylsilyl-1-deoxy-D-mannitol
  参考文献：
  名称：

  Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis

  摘要：

  Herein we report the Synthesis of symmetrical C-linked and pseudo-symmetrical O-linked disaccharides structurally related to Araf motifs present in the cell wall of MTB. Their activity in a competition-based arabinosyltransferase assay using [C-14]-DPA as the glycosyl donor is also presented. In addition, in vitro inhibitory activity for the disaccharides was determined in a colorimetric broth microdilution assay system against MTB H37Ra and Mycobacterium avium. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.099