1-allyl-4-tert-butyl-1-methoxycyclohexane | 74571-44-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-allyl-4-tert-butyl-1-methoxycyclohexane
• CAS: 74571-44-1
• 化学式: C₁₄H₂₆O
• 分子量: 210.36
• InChiKey: FHHKMUQBPVHGQA-MQMHXKEQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  4-叔丁基环己酮 在 对甲苯磺酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 1-allyl-4-tert-butyl-1-methoxycyclohexane 、 1-allyl-4-tert-butyl-1-methoxycyclohexane
  参考文献：
  名称：

  Mesoporous aluminosilicate-catalyzed allylation of carbonyl compounds and acetals

  摘要：

  A mesoporous aluminosilicate (Al-MCM-41) was found to be an effective heterogeneous catalyst for the reaction of both carbonyl compounds and acetals with allylsilanes to afford the corresponding homoallyl silyl ethers and homoallyl alkyl ethers, respectively. Both the mesoporous structure and the presence of aluminum moiety were indispensable for the high catalytic activity of Al-MCM-41. Moreover, Al-MCM-41 could catalyze the reaction of acetals chemoselectively in the presence of the corresponding carbonyl compounds. The solid acid catalyst Al-MCM-41 could be recovered easily by filtration and could be reused three times without a significant loss of catalytic activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.055

文献信息

• Trimethysilyl triflate in organic synthesis11Part 11 of this series. Part 10: S. Murata and R. Noyori, Tetrahedron Letters 2107 (1981).
  作者：R. Noyori、S. Murata、M. Suzuki

  DOI：10.1016/s0040-4020(01)93263-6

  日期：——

  Trimethylsilyl triflate is a powerful silylating agent for organic compounds and acts as a catalyst which accelerates a variety of nucleophilic reactions in aprotic media. The reactions proceed via one-center, electrophilic coordination of the silyl group to hetero functional groups and exhibit unique selectivities.

  三氟甲磺酸三甲基甲硅烷基酯是有机化合物的强大甲硅烷基化剂，并充当催化剂，可加速非质子介质中的各种亲核反应。反应通过甲硅烷基与杂官能团的单中心亲电配位进行，并表现出独特的选择性。
• Trimethylsilyl trifluoromethanesulfonate as a catalyst of the reaction of allyltrimethylsilane and acetals
  作者：T. Tsunoda、M. Suzuki、R. Noyori

  DOI：10.1016/s0040-4039(00)93627-x

  日期：1980.1

  In the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonate, allyltrimethylsilane reacts with acetals to give the corresponding homoallyl ethers in high yields.

  在催化量的三氟甲磺酸三甲基甲硅烷基酯的存在下，烯丙基三甲基硅烷与乙缩醛反应以高收率得到相应的均烯丙基醚。
• SOLID ACID-CATALYZED ALLYLATION OF ACETALS AND CARBONYL COMPOUNDS WITH ALLYLIC SILANES
  作者：Motomitsu Kawai、Makoto Qnaka、Yusuke Izumi

  DOI：10.1246/cl.1986.381

  日期：1986.3.5

  Acetals and carbonyl compounds are allylated with allylic silanes in good yields in the presence of a catalytic amount of clay montmorillonite.

  在一定量的粘土蒙脱石催化下，乙酸和羰基化合物可与烯丙基硅烷发生烯丙基化反应，而且收率很高。