| 1418179-41-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1418179-41-5
• 化学式: C₄₆H₇₈ClN₉O₂₅
• 分子量: 1192.62
• InChiKey: KPRPGRDMPSQPPQ-BICSFYCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.85
• 重原子数：
  81.0
• 可旋转键数：
  40.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  454.88
• 氢给体数：
  12.0
• 氢受体数：
  34.0

反应信息

• 作为反应物：
  描述：

  在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 以86%的产率得到
  参考文献：
  名称：

  Glycofullerenes Inhibit Viral Infection

  摘要：

  Water-soluble glycofullerenes based on a hexakis-adduct of [60]fullerene with an octahedral addition pattern are very attractive compounds providing a spherical presentation of carbohydrates. These tools have been recently described and they have been used to interact with lectins in a multivalent manner. Here, we present the use of these glycofullerenes, including new members with 36 mannoses, as compounds able to inhibit a DC-SIGN-dependent cell infection by pseudotyped viral particles. The results obtained in these experiments demonstrate for the first time that these glycoconjugates are adequate to inhibit efficiently an infection process, and therefore, they can be considered as very promising and interesting tools to interfere in biological events where lectins such as DC-SIGN are involved.

  DOI：

  10.1021/bm3016658
• 作为产物：
  描述：

  2-[2-[2-(2-chloroethoxy)ethoxy]ethoxy]ethoxymethyl tris(prop-2-yn-1-yloxymethyl)methane 、 2-azidoethyl α-D-mannopyranoside 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 、 三[(1-苄基-1H-1,2,3-三唑-4-基)甲基]胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.42h， 以85%的产率得到
  参考文献：
  名称：

  Glycofullerenes Inhibit Viral Infection

  摘要：

  Water-soluble glycofullerenes based on a hexakis-adduct of [60]fullerene with an octahedral addition pattern are very attractive compounds providing a spherical presentation of carbohydrates. These tools have been recently described and they have been used to interact with lectins in a multivalent manner. Here, we present the use of these glycofullerenes, including new members with 36 mannoses, as compounds able to inhibit a DC-SIGN-dependent cell infection by pseudotyped viral particles. The results obtained in these experiments demonstrate for the first time that these glycoconjugates are adequate to inhibit efficiently an infection process, and therefore, they can be considered as very promising and interesting tools to interfere in biological events where lectins such as DC-SIGN are involved.

  DOI：

  10.1021/bm3016658