[(4aS,5R,6S,7S,7aS)-7-[(1S,3S)-4-[tert-butyl(dimethyl)silyl]oxy-1-[tert-butyl(diphenyl)silyl]oxy-3-methylbutyl]-3-(cyclohepten-1-yl)-4a,6-dimethyl-1-methylidene-3,4,5,6,7,7a-hexahydrocyclopenta[c]pyran-5-yl]oxy-tert-butyl-dimethylsilane | 1161082-93-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(4aS,5R,6S,7S,7aS)-7-[(1S,3S)-4-[tert-butyl(dimethyl)silyl]oxy-1-[tert-butyl(diphenyl)silyl]oxy-3-methylbutyl]-3-(cyclohepten-1-yl)-4a,6-dimethyl-1-methylidene-3,4,5,6,7,7a-hexahydrocyclopenta[c]pyran-5-yl]oxy-tert-butyl-dimethylsilane
• CAS: 1161082-93-4
• 化学式: C₅₁H₈₄O₄Si₃
• 分子量: 845.482
• InChiKey: IZEJBVJLDXNCQB-DSINODKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.45
• 重原子数：
  58
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [(4aS,5R,6S,7S,7aS)-7-[(1S,3S)-4-[tert-butyl(dimethyl)silyl]oxy-1-[tert-butyl(diphenyl)silyl]oxy-3-methylbutyl]-3-(cyclohepten-1-yl)-4a,6-dimethyl-1-methylidene-3,4,5,6,7,7a-hexahydrocyclopenta[c]pyran-5-yl]oxy-tert-butyl-dimethylsilane 以 4-异丙基甲苯 为溶剂， 反应 6.0h， 以48%的产率得到
  参考文献：
  名称：

  Claisen Ring Expansion Approach toward the CDEF Ring System of Lancifodilactone G

  摘要：

  The fused CDEF ring system of lancifodilactone G is assembled via a Nozaki-Hiyama-Kishi cross-coupling reaction and a Petasis-Claisen ring expansion sequence as the key strategic steps.

  DOI：

  10.3987/com-08-s(d)2
• 作为产物：
  描述：

  (4aS,5R,6S,7S,7aS)-5-[tert-butyl(dimethyl)silyl]oxy-7-[(1S,3S)-4-[tert-butyl(dimethyl)silyl]oxy-1-[tert-butyl(diphenyl)silyl]oxy-3-methylbutyl]-3-(cyclohepten-1-yl)-4a,6-dimethyl-3,4,5,6,7,7a-hexahydrocyclopenta[c]pyran-1-one 在 dimethyltitanocene 作用下， 以 甲苯 为溶剂， 反应 1.5h， 以66%的产率得到[(4aS,5R,6S,7S,7aS)-7-[(1S,3S)-4-[tert-butyl(dimethyl)silyl]oxy-1-[tert-butyl(diphenyl)silyl]oxy-3-methylbutyl]-3-(cyclohepten-1-yl)-4a,6-dimethyl-1-methylidene-3,4,5,6,7,7a-hexahydrocyclopenta[c]pyran-5-yl]oxy-tert-butyl-dimethylsilane
  参考文献：
  名称：

  Claisen Ring Expansion Approach toward the CDEF Ring System of Lancifodilactone G

  摘要：

  The fused CDEF ring system of lancifodilactone G is assembled via a Nozaki-Hiyama-Kishi cross-coupling reaction and a Petasis-Claisen ring expansion sequence as the key strategic steps.

  DOI：

  10.3987/com-08-s(d)2

文献信息

• Claisen Ring Expansion Approach toward the CDEF Ring System of Lancifodilactone G
  作者：Leo A. Paquette、Kwong Wah Lai

  DOI：10.3987/com-08-s(d)2

  日期：——

  The fused CDEF ring system of lancifodilactone G is assembled via a Nozaki-Hiyama-Kishi cross-coupling reaction and a Petasis-Claisen ring expansion sequence as the key strategic steps.