Disodium D-mannose 6-phosphate | 33068-18-7

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Disodium D-mannose 6-phosphate
• 英文别名: disodium;[(2R,3R,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexyl] phosphate
• CAS: 33068-18-7
• 化学式: C6H11Na2O9P
• 分子量: 304.1
• InChiKey: VQLXCAHGUGIEEL-OXIHULNRSA-L

物化性质

• 溶解度：
  H2O：50 mg/mL，澄清，无色

计算性质

• 辛醇/水分配系数(LogP)：
  -10.52
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  170
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• WGK Germany：
  3

文献信息

• [EN] ANTI-AGING COSMETIC COMPOSITION<br/>[FR] COMPOSITION COSMÉTIQUE ANTI-ÂGE
  申请人：GIVAUDAN SA

  公开号：WO2020201185A1

  公开（公告）日：2020-10-08

  A cosmetic active agent comprising a mixture of mannose-6-phosphate and mannose is disclosed.

  本发明公开了一种包含甘露醇-6-磷酸和甘露醇混合物的化妆品活性剂。
• HYDROPHILIC NANOPARTICLES SURFACE-MODIFIED WITH MONOSACCHARIDE PHOSPHATE OR MONOSACCHARIDE PHOSPHATE DERIVATIVES, ITS COLLOIDAL SOLUTION AND USE THEREOF
  申请人：HANWHA CHEMICAL CORPORATION

  公开号：US20140161734A1

  公开（公告）日：2014-06-12

  Disclosed are a composition including hydrophilic nanoparticles that have a monosaccharide-phosphate or a derivative thereof adhered to the surface thereof, a colloidal solution of the composition dispersed in water, and a magnetic resonance imaging contrast agent including the colloidal solution. According to the present invention, nanoparticles having biocompatibility and excellent water-dispersibility can be prepared by modifying the surface of inorganic nanoparticles. The prepared nanoparticles may be effectively used in a variety of applications including, for example, in vivo imaging applications such as an MRI contrast agent, nano-electronic convergence technologies such as a quantum dot light emitting device, biomedical applications such as hyperthermia, or the like. Moreover, compared to existing nanoparticles dispersed by a dispersion stabilizer known in the art, excellent dispersion stability and a relatively small hydrodynamic diameter may be attained.

  本发明涉及一种包括亲水性纳米颗粒的组合物，其表面附着有单糖酸盐或其衍生物，以及该组合物在水中分散的胶体溶液和包括该胶体溶液的磁共振成像对比剂。根据本发明，通过修饰无机纳米颗粒的表面，可以制备具有生物相容性和优异的水分散性的纳米颗粒。所制备的纳米颗粒可在多种应用中有效使用，包括体内成像应用，如MRI对比剂，纳米电子融合技术，如量子点发光装置，生物医学应用，如超热疗等。此外，与现有的通过分散稳定剂分散的纳米颗粒相比，可以获得优异的分散稳定性和相对较小的流体动力学直径。
• Method for analysis of saccharides
  申请人：JCR Pharmaceuticals CO., LTD.

  公开号：EP2230518A1

  公开（公告）日：2010-09-22

  Disclosed is an improved post-column fluorimetric determination-boric acid complex anion exchange method which allows analysis of mannose-6-phosphate. The disclosed method is a method for separation analysis of reducing sugars using column chromatography, comprising loading a sample onto an anion exchange column, washing the column by allowing to flow a sufficient volume of a first mobile phase consisting of an aqueous solution of a predetermined concentration of boric acid containing a predetermined concentration of a water-soluble inorganic salt through the column, supplying a second mobile phase with an elevated concentration of the salt to elute the reducing sugars, adding to the eluate a basic amino acid, heating, and continuously measuring and recording the intensity of fluorescent light emitted under irradiation with excitation light.

  本发明公开了一种改进的柱后荧光测定-硼酸复合物阴离子交换法，可用于分析 6-磷酸甘露糖。所公开的方法是一种使用柱色谱法分离分析还原糖的方法，包括将样品装入阴离子交换柱，通过让足够体积的第一流动相流过柱子来清洗柱子，第一流动相由预定浓度的硼酸水溶液组成，其中含有预定浓度的水溶性无机盐、提供含有较高浓度盐的第二流动相以洗脱还原糖，向洗脱液中加入碱性氨基酸，加热，并连续测量和记录在激发光照射下发出的荧光强度。
• Kosmetische Zubereitungen mit hoch-elastischer Textur
  申请人：Beiersdorf AG

  公开号：EP2364688A2

  公开（公告）日：2011-09-14

  Es werden kosmetische oder dermatologische Zubereitung auf Basis einer O/W-Emulsion beschrieben, die ein oder mehrere Stearinsäure-Emulgatoren und ein oder mehrere Polyacrylsäure-Verdicker im Verhältnis 10:1 bis 1:1 aufweisen. Die Zubereitungen weisen eine hoch elastische Textur bei geringer Viskosität auf.

  描述了基于水包油型乳液的化妆品或皮肤学制剂，该制剂含有一种或多种硬脂酸乳化剂和一种或多种聚丙烯酸增稠剂，两者的比例为 10:1 至 1:1。这些制剂具有高弹性、低粘度的质地。
• SUGAR ANALYSIS DEVICE AND ANALYSIS METHOD
  申请人：JCR Pharmaceuticals CO., LTD.

  公开号：EP2565644A1

  公开（公告）日：2013-03-06

  Disclosed is a method separation analysis of reducing sugars with enhanced sensitivity and an analytical apparatus therefore employing the post-column fluorescence detection/boric acid complex anion exchange method. The method disclosed is a method for analysis of reducing sugars using the post-column fluorescence detection/boric acid complex anion exchange method, and characterized in that a back-pressure generator is installed in the flow path between the heater, which is for causing a reaction by heating a sample separated by column chromatography with a basic amino acid, and a fluorometric detector.

  本发明公开了一种灵敏度更高的还原糖分离分析方法，以及采用柱后荧光检测/硼酸络合阴离子交换法的分析装置。本发明公开了一种使用柱后荧光检测/硼酸络合阴离子交换法分析还原糖的方法，其特征在于在加热器（用于加热通过柱层析分离的样品，使其与碱性氨基酸发生反应）和荧光检测器之间的流路中安装了背压发生器。