(E)-(3R,4R,6S)-4,6-Diethyl-3,6-dihydroxy-8,10-dimethyl-tetradec-8-enoic acid methyl ester | 609371-48-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (E)-(3R,4R,6S)-4,6-Diethyl-3,6-dihydroxy-8,10-dimethyl-tetradec-8-enoic acid methyl ester
• CAS: 609371-48-4
• 化学式: C₂₁H₄₀O₄
• 分子量: 356.546
• InChiKey: JZENPHJLZXHRFP-FNRQUZLSSA-N

反应信息

• 作为反应物：
  描述：

  (R)-(+)-α-甲氧基-α-(三氟甲基)苯乙酸 、 (E)-(3R,4R,6S)-4,6-Diethyl-3,6-dihydroxy-8,10-dimethyl-tetradec-8-enoic acid methyl ester 在 吡啶 作用下， 以1.3 mg的产率得到(E)-(3R,4R,6S)-4,6-Diethyl-6-hydroxy-8,10-dimethyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-tetradec-8-enoic acid methyl ester
  参考文献：
  名称：

  A New α,β,γ,δ-Unsaturated carboxylic acid and three new cyclic peroxides from the marine sponge, Monotria japonica, which selectively lyse starfish oocytes without affecting nuclear morphology

  摘要：

  The marine sponge Monotria japonica contains cytolytic constituents, which have been fractionated to a new alpha,beta,gamma,delta-unsaturated carboxylic acid designated monotriajaponide A (1) and three new cyclic peroxides designated monotriajaponides B (2), C (3), and D (4), in addition to a known peroxide (5) and a known alpha,beta-unsaturated ester (6). The structures were determined on the basis of spectroscopic data. Compounds 1-5 lysed immature starfish (Asterina pectinifera) oocytes without affecting nuclear morphology at the minimum effective concentrations of 50, 6.3, 6.3, 6.3, and 13 mug/mL, respectively. On the other hand, compound 6, at the minimum effective concentration of 25 mug/mL, lysed both oocyte's plasma membrane and the nuclear envelope. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00030-0
• 作为产物：
  描述：

  [(3R,4R,6S)-6-((E)-2,4-Dimethyl-oct-1-enyl)-4,6-diethyl-[1,2]dioxan-3-yl]-acetic acid methyl ester 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.32 kPa 条件下， 反应 1.0h， 以3.9 mg的产率得到(E)-(3R,4R,6S)-4,6-Diethyl-3,6-dihydroxy-8,10-dimethyl-tetradec-8-enoic acid methyl ester
  参考文献：
  名称：

  A New α,β,γ,δ-Unsaturated carboxylic acid and three new cyclic peroxides from the marine sponge, Monotria japonica, which selectively lyse starfish oocytes without affecting nuclear morphology

  摘要：

  The marine sponge Monotria japonica contains cytolytic constituents, which have been fractionated to a new alpha,beta,gamma,delta-unsaturated carboxylic acid designated monotriajaponide A (1) and three new cyclic peroxides designated monotriajaponides B (2), C (3), and D (4), in addition to a known peroxide (5) and a known alpha,beta-unsaturated ester (6). The structures were determined on the basis of spectroscopic data. Compounds 1-5 lysed immature starfish (Asterina pectinifera) oocytes without affecting nuclear morphology at the minimum effective concentrations of 50, 6.3, 6.3, 6.3, and 13 mug/mL, respectively. On the other hand, compound 6, at the minimum effective concentration of 25 mug/mL, lysed both oocyte's plasma membrane and the nuclear envelope. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00030-0