(1S,2R)-1-(N-methyl aminomethyl)-2-hydroxyl-7,7-dimethylbicyclo[2.2.1]heptane | 291302-05-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S,2R)-1-(N-methyl aminomethyl)-2-hydroxyl-7,7-dimethylbicyclo[2.2.1]heptane
• 英文别名: (1R,2R,4R)-7,7-dimethyl-1-(methylaminomethyl)bicyclo[2.2.1]heptan-2-ol
• CAS: 291302-05-1
• 化学式: C₁₁H₂₁NO
• 分子量: 183.294
• InChiKey: AMUCWMUCJZVTQR-FXPVBKGRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.39
• 重原子数：
  13.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.26
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  二苯基氯化膦 、 (1S,2R)-1-(N-methyl aminomethyl)-2-hydroxyl-7,7-dimethylbicyclo[2.2.1]heptane 在 三乙胺 作用下， 以 苯 为溶剂， 反应 24.0h， 以58%的产率得到N,O-bis(diphenylphosphino)-(1S,2R)-1-(N-methylamino)methyl-2-hydroxyl-7,7-dimethylbicyclo[2.2.1]heptane
  参考文献：
  名称：

  Asymmetric hydrogenation of dehydroamino acid derivatives catalyzed by a new aminophosphine phosphinite ligand derived from ketopinic acid

  摘要：

  A new chiral aminophosphine phosphinite N,O-bis(diphenylphosphino)-(1S,2R)-1-(N-methylamino) methyl-2-hydroxyl-7,7-dimethylbicyclo[2.2.1]heptane was synthesized from ketopinic acid and its application to the asymmetric hydrogenation of dehydroamino acid derivatives examined. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00164-6
• 作为产物：
  描述：

  (1S,2R)-2-hydroxyl-7,7-dimethylbicyclo[2.2.1]heptane-1-N-methylcarboxamide 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以90%的产率得到(1S,2R)-1-(N-methyl aminomethyl)-2-hydroxyl-7,7-dimethylbicyclo[2.2.1]heptane
  参考文献：
  名称：

  Asymmetric hydrogenation of dehydroamino acid derivatives catalyzed by a new aminophosphine phosphinite ligand derived from ketopinic acid

  摘要：

  A new chiral aminophosphine phosphinite N,O-bis(diphenylphosphino)-(1S,2R)-1-(N-methylamino) methyl-2-hydroxyl-7,7-dimethylbicyclo[2.2.1]heptane was synthesized from ketopinic acid and its application to the asymmetric hydrogenation of dehydroamino acid derivatives examined. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00164-6