Maduralide | 135288-70-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Maduralide
• 英文别名: (7E,11E,19E)-14-[(2S,3R,4R,5R,6S)-3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4,22-dihydroxy-24-(3-hydroxypentan-2-yl)-5,7,9,13,15,17,23-heptamethyl-1-oxacyclotetracosa-7,11,19-triene-2,6,10,18-tetrone
• CAS: 135288-70-9
• 化学式: C₄₂H₆₈O₁₃
• 分子量: 780.994
• InChiKey: FCXJEHUXTNOFKT-ZNUHQKBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  55
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  206
• 氢给体数：
  5
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 Maduralide 在 吡啶 作用下， 生成 Acetic acid (2S,3R,4R,5R,6S)-5-acetoxy-4-methoxy-6-methyl-2-[(6E,14E,16Z,18E)-4,16,22-triacetoxy-2-(2-acetoxy-1-methyl-butyl)-3,9,11,13,17,19,21-heptamethyl-8,20,24-trioxo-oxacyclotetracosa-6,14,16,18-tetraen-12-yloxy]-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Structure determination of maduralide: a new 24-membered ring macrolide glycoside produced by a marine bacterium (actinomycetales)

  摘要：

  Maduralide (1), a novel macrolide possessing a 24-membered ring, was isolated from a marine bacterium grown in liquid culture. The structure of this new metabolite was determined by spectroscopic methods.

  DOI：

  10.1016/s0040-4039(00)79914-x

文献信息

• [EN] BRIDGED MACROCYCLIC COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] COMPOSES MACROCYCLIQUES PONTES ET PROCEDES DE PREPARATION DESDITS COMPOSES
  申请人：ENANTA PHARM INC

  公开号：WO2005080408A1

  公开（公告）日：2005-09-01

  The present invention provides a method for preparing bridged macrocyclic compounds comprising the step of reacting a macrocyclic compound characterized by having at least two nucleophilic moieties with a bifunctional bridging reagent optionally in the presence of a catalyst, thereby producing a bridged macrocyclic product.

  本发明提供了一种制备桥联大环化合物的方法，包括以下步骤：将至少具有两个亲核基团的大环化合物与双功能桥接试剂反应，可选地在催化剂的存在下进行，从而产生桥联大环产物。
• Bridged macrocyclic compounds and processes for the preparation thereof
  申请人：Or Sun Yat

  公开号：US20050009761A1

  公开（公告）日：2005-01-13

  The present invention provides a method for preparing bridged macrocyclic compounds comprising the step of reacting a macrocyclic compound characterized by having at least two nucleophilic moieties with a bifunctional bridging reagent optionally in the presence of a catalyst, thereby producing a bridged macrocyclic product.

  本发明提供了一种制备桥接大环化合物的方法，该方法包括以下步骤：使具有至少两个亲核分子的大环化合物与双官能桥接试剂（可选择在催化剂存在下）反应，从而生成桥接大环产物。
• US7910558B2
  申请人：——

  公开号：US7910558B2

  公开（公告）日：2011-03-22