(13S)-pimaranoic acid-(18) | 17611-06-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (13S)-pimaranoic acid-(18)
• 英文别名: (13S)-Pimaransaeure-(18)；Tetrahydroisopimaric acid；(1R,4aR,4bS,7S,8aS,10aR)-7-ethyl-1,4a,7-trimethyl-3,4,4b,5,6,8,8a,9,10,10a-decahydro-2H-phenanthrene-1-carboxylic acid
• CAS: 17611-06-2
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.489
• InChiKey: UPTDGYZWMBPKCL-LOBZHTCKSA-N

物化性质

• 熔点：
  172-174 °C
• 沸点：
  414.3±13.0 °C(Predicted)
• 密度：
  0.982±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 、 铂 作用下， 生成 (13S)-pimaranoic acid-(18)
  参考文献：
  名称：

  Clinico-pathological profile of pediatric lymphadenopathy

  摘要：

  Objective: To study the clinico-pathological profile of significant pediatric peripheral lymphadenopathy and to arrrive at an etiological diagnosis. Methods: Prospective study in a tertiary care hospital setting. One hundred consecutive children reporting to pediatric OPD from 1 January 1995 to 31 December 1998, aged 1 month to 12 years were studied. Results: The commonest aetiology diagnosed was tubercular lymphadenitis in 35% cases, followed by chronic tonsillopharyngitis in 15% cases. Lymphomas, AIDS and infectious mononucleosis constituted 3, 2 and 1 cases each. Aetiology could not be ascertained in 44 (44%) children even after detailed haematological, microbiological, radiological and serological investigations. FNAC's sensitivity and specificity as compared to 'gold standard of excision lymph node biopsy was 94% and 100% respectively. Conclusion: Tubercular lymphadenitis was the commonest treatable entity of significant pediatric peripheral lymphadenopathy. A majority of the cases even after thorough evaluation, remained undiagnosed. FNAC as a diagnostic modality is almost as sensitive and as specific as excision lymph node biopsy when an adequate aspirate is examined by expert eyes.

  DOI：

  10.1007/bf02724385

文献信息

• THE STEREOCHEMISTRY OF THE TETRAHYDROPIMARIC ACIDS
  作者：J. W. ApSimon、P. V. Demarco、J. Lemke

  DOI：10.1139/v65-390

  日期：1965.10.1

  Evidence is presented that the fully reduced derivatives of pimaric acid (I), sandaracopimaric acid (II), and isopimaric acid (III) have trans–anti–trans fused skeletons. The implications of this observation are discussed.

  有证据表明，海松酸 (I)、山达海松酸 (II) 和异海松酸 (III) 的完全还原衍生物具有反式-反-反式融合骨架。讨论了这一观察结果的含义。
• 128. Miro resin. Part II. The resin acids
  作者：C. W. Brandt、L. G. Neubauer

  DOI：10.1039/jr9400000683

  日期：——
• Ukita et al., Pharmaceutical Bulletin, 1955, vol. 3, p. 441,445
  作者：Ukita et al.

  DOI：——

  日期：——