Acetic acid (1R,5S)-5-(1-hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enyl ester | 137821-90-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Acetic acid (1R,5S)-5-(1-hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enyl ester
• CAS: 137821-90-0
• 化学式: C₁₂H₂₀O₃
• 分子量: 212.289
• InChiKey: DVQXSZLFASOBJB-WDEREUQCSA-N

反应信息

• 作为产物：
  描述：

  Acetic acid 5-(1-hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enyl ester 以 丙酮 为溶剂， 反应 96.0h， 生成 反式-索布瑞醇 、 Acetic acid (1R,5S)-5-(1-hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enyl ester
  参考文献：
  名称：

  Resolution of (±)-trans-sobrerol by lipase PS-catalyzed transesterification and effects of organic solvents on enantioselectivity

  摘要：

  Resolution of the mucolytic drug (+/-)-trans-sobrerol (1) was achieved by transesterification with vinyl acetate in organic media, catalyzed by free or immobilized Lipase PS. The enantioselectivity of the enzyme was markedly influenced by the nature of the organic solvent, but there was no correlation between enantiomeric ratio values (70-500) and either the hydrophobicity or the dielectric constant of the medium. With the enzyme immobilized onto Hyflo Super Cell and t-amyl alcohol as the solvent, the selectivity of Lipase PS for (-)-1 was extremely high and, at 50 % conversion both (-)-trans-sobrerol and (+)-trans-sobrerol monoacetate were obtained in practically 100 % optical purity.

  DOI：

  10.1016/s0957-4166(00)82205-3