| 1193357-12-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 1193357-12-8
• 化学式: C₁₅H₂₄O₄
• 分子量: 268.353
• InChiKey: ULJNVOSRCZZRJL-NZDOLIBDSA-N

反应信息

• 作为反应物：
  描述：

  、 4-溴苯甲酰氯 在 吡啶 作用下， 反应 17.0h， 以1.1 mg的产率得到
  参考文献：
  名称：

  Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220

  摘要：

  Berkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC(50) values of 1.1-7.5 mu g/mL, and these compounds also showed antimalarial activity with respective IC(50) of 3.1 and 2.8 mu g/mL. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.08.077
• 作为产物：
  描述：

  berkleasmin A 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 168.0h， 以5.9 mg的产率得到
  参考文献：
  名称：

  Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220

  摘要：

  Berkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC(50) values of 1.1-7.5 mu g/mL, and these compounds also showed antimalarial activity with respective IC(50) of 3.1 and 2.8 mu g/mL. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.08.077