4'-(bromomethyl)-3-hydroxybiphenyl-2-propene | 1041196-74-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-(bromomethyl)-3-hydroxybiphenyl-2-propene
• CAS: 1041196-74-0
• 化学式: C₁₆H₁₅BrO
• 分子量: 303.198
• InChiKey: NOMGTRFAWJKHRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.99
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4'-(bromomethyl)-3-hydroxybiphenyl-2-propene 在 sodium periodate 、 四氧化锇 作用下， 以 1,4-二氧六环 、 水 、 叔丁醇 为溶剂， 反应 2.0h， 以54%的产率得到4'-(bromomethyl)-3-hydroxybiphenyl-2-carbaldehyde
  参考文献：
  名称：

  Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans

  摘要：

  In this work we reported the synthesis of new potential AT1 antagonists through the replacement of the biphenyltetrazole portion of the losartan with biphenylaldoximic (2) and phenylsalicylaldoximic (3a) moieties. Moreover, also the trifluoromethylpyrazole analogue of 3a (3b) was prepared. The new compounds synthesized were evaluated for their AT1 affinity through binding assay carried out on rat liver membranes using [(125)I]Sar1,Ile8-angiotensina II as radioligand.

  DOI：

  10.3987/com-07-11309
• 作为产物：
  描述：

  4'-(hydroxymethyl)-3-hydroxybiphenyl-2-propene 在 四溴化碳 、 三苯基膦 作用下， 反应 4.0h， 以41%的产率得到4'-(bromomethyl)-3-hydroxybiphenyl-2-propene
  参考文献：
  名称：

  Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans

  摘要：

  In this work we reported the synthesis of new potential AT1 antagonists through the replacement of the biphenyltetrazole portion of the losartan with biphenylaldoximic (2) and phenylsalicylaldoximic (3a) moieties. Moreover, also the trifluoromethylpyrazole analogue of 3a (3b) was prepared. The new compounds synthesized were evaluated for their AT1 affinity through binding assay carried out on rat liver membranes using [(125)I]Sar1,Ile8-angiotensina II as radioligand.

  DOI：

  10.3987/com-07-11309