2-(α-(3,4-diaminophenoxy)acetyl)-6-(dimethylamino)naphthalene | 1552301-15-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(α-(3,4-diaminophenoxy)acetyl)-6-(dimethylamino)naphthalene
• CAS: 1552301-15-1
• 化学式: C₂₀H₂₁N₃O₂
• 分子量: 335.406
• InChiKey: MSCJELUSJQPWNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.33
• 重原子数：
  25.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  81.58
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(α-(3,4-diaminophenoxy)acetyl)-6-(dimethylamino)naphthalene 在 氧气 、 氧化亚氮 作用下， 以 乙醇 为溶剂， 生成 2-((1H-benzo[d][1,2,3]triazol-6-yl)oxy)-1-(6-(dimethylamino)naphthalen-2-yl)ethan-1-one
  参考文献：
  名称：

  Highly selective two-photon fluorescent probe for imaging of nitric oxide in living cells

  摘要：

  A new two-photon fluorescent probe, ADNO, for nitric oxide (NO) based on intramolecular photoinduced electron transfer (PET) mechanism displays a rapid response to NO with a remarkable fluorescent enhancement in PBS buffer. The excellent chemoselectivity of ADNO for NO over other ROS/RNS (reactive oxygen species or nitrogen species) and common metal ions was observed. Moreover, ADNO has been successfully applied in fluorescence imaging of NO of living cells using both one-photon microscopy (OPM) and two-photon microscopy (TPM). (C) 2013 Guo-Ping Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.11.024
• 作为产物：
  描述：

  1-(6-二甲胺基萘-2-基)乙酮 在 sodium dithionite 、 氢溴酸 、 溴 、 potassium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 反应 12.0h， 生成 2-(α-(3,4-diaminophenoxy)acetyl)-6-(dimethylamino)naphthalene
  参考文献：
  名称：

  Highly selective two-photon fluorescent probe for imaging of nitric oxide in living cells

  摘要：

  A new two-photon fluorescent probe, ADNO, for nitric oxide (NO) based on intramolecular photoinduced electron transfer (PET) mechanism displays a rapid response to NO with a remarkable fluorescent enhancement in PBS buffer. The excellent chemoselectivity of ADNO for NO over other ROS/RNS (reactive oxygen species or nitrogen species) and common metal ions was observed. Moreover, ADNO has been successfully applied in fluorescence imaging of NO of living cells using both one-photon microscopy (OPM) and two-photon microscopy (TPM). (C) 2013 Guo-Ping Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.11.024