Acetic acid (3S,4S)-4-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-ylamino]-1,2,3,4-tetrahydro-phenanthren-3-yl ester | 144671-34-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: Acetic acid (3S,4S)-4-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-ylamino]-1,2,3,4-tetrahydro-phenanthren-3-yl ester
• CAS: 144671-34-1
• 化学式: C₂₆H₂₇N₅O₆
• 分子量: 505.53
• InChiKey: GJRAEJRKBNOJLS-UDGWLPKNSA-N

反应信息

• 作为反应物：
  描述：

  Acetic acid (3S,4S)-4-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-ylamino]-1,2,3,4-tetrahydro-phenanthren-3-yl ester 在 2,6-二甲基吡啶 、 lithium carbonate 作用下， 生成
  参考文献：
  名称：

  Epoxide and diol epoxide adducts of polycyclic aromatic hydrocarbons at the exocyclic amino group of deoxyguanosine

  摘要：

  Synthesis and separation of the diastereomeric trans N2-2'-deoxyguanosine adducts of tetrahydrophenanthrene 3,4-epoxide and benzo[a]pyrene 7,8-diol 9, 10-epoxide (benzylic hydroxyl group and epoxide oxygen trans), as well as the incorporation of the former into the pentanucleotide TpApG*pApT, are described.

  DOI：

  10.1016/s0040-4039(00)92649-2
• 作为产物：
  描述：

  6-Benzyloxy-9-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-fluoro-9H-purine 在 palladium on activated charcoal 2,6-二甲基吡啶 、 六甲基二硅氧烷 、 氢气 作用下， 以 二甲基亚砜 为溶剂， 90.0 ℃ 、101.33 kPa 条件下， 反应 6.58h， 生成 Acetic acid (3S,4S)-4-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-ylamino]-1,2,3,4-tetrahydro-phenanthren-3-yl ester
  参考文献：
  名称：

  Epoxide and diol epoxide adducts of polycyclic aromatic hydrocarbons at the exocyclic amino group of deoxyguanosine

  摘要：

  Synthesis and separation of the diastereomeric trans N2-2'-deoxyguanosine adducts of tetrahydrophenanthrene 3,4-epoxide and benzo[a]pyrene 7,8-diol 9, 10-epoxide (benzylic hydroxyl group and epoxide oxygen trans), as well as the incorporation of the former into the pentanucleotide TpApG*pApT, are described.

  DOI：

  10.1016/s0040-4039(00)92649-2