(4-Oxo-1-adamantyl) carbamate | 1358764-13-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-Oxo-1-adamantyl) carbamate
• CAS: 1358764-13-2
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: MBMJZILAYHFYCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-Oxo-1-adamantyl) carbamate 在 盐酸 、 sodium tetrahydroborate 、 5%-palladium/activated carbon 、 氢气 、 溶剂黄146 、 sodium hydroxide 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 、 甲醇 、 二氯甲烷 、 N,N-二甲基乙酰胺 、 水 为溶剂， 30.0 ℃ 、200.0 kPa 条件下， 反应 9.0h， 生成 [4-[[1-(3-Acetamido-3-methylbut-1-enyl)-5-propan-2-yloxypyrazole-4-carbonyl]amino]-1-adamantyl] carbamate
  参考文献：
  名称：

  EP2687515

  摘要：

  公开号：
• 作为产物：
  描述：

  5-羟基-2-金刚烷酮 、 氯磺酰异氰酸酯 在 水 作用下， 以 丙酮 为溶剂， 反应 10.5h， 以85.3%的产率得到(4-Oxo-1-adamantyl) carbamate
  参考文献：
  名称：

  EP2604591

  摘要：

  公开号：

文献信息

• PROCESS FOR PREPARING AMINOADAMANTYL CARBAMATE DERIVATIVES
  申请人：Shionogi & Co., Ltd.

  公开号：EP2604591A1

  公开（公告）日：2013-06-19

  Disclosed is a process for producing an aminoadamantane carbamate derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor. A process for producing an acid addition salt of a compound represented by the Formula (II): or a solvate of the acid addition salt, wherein R1 and R2 are each independently hydrogen, substituted or unsubstituted alkyl or the like; R3 and R4 are each independently hydrogen, substituted or unsubstituted alkyl or the like; and R5 and R6 are each independently hydrogen, halogen, carboxy, nitro, substituted or unsubstituted alkyl or the like; which comprises separating an acid addition salt of a compound represented by the Formula (II) or a solvate of the acid addition salt by adding an acid to a mixture of syn isomer and anti isomer of a compound represented by the Formula (I): wherein R1, R2, R3, R4, R5, and R6 are as defined above, in the presence of a solvent.

  本发明公开了一种生产氨基金刚烷氨基甲酸酯衍生物的工艺，该衍生物可用作 11βHSD-1 抑制剂的重要中间体。 一种生产由式（II）代表的化合物的酸加成盐的工艺： 或该酸加成盐的溶液，其中 R1 和 R2 各自独立地为氢、取代或未取代的烷基或类似物；R3 和 R4 各自独立地为氢、取代或未取代的烷基或类似物；以及 R5 和 R6 各自独立地为氢、卤素、羧基、硝基、取代或未取代的烷基或类似物； 其中包括通过向式（I）所代表化合物的同分异构体和反异构体混合物中加入酸，分离出式（II）所代表化合物的酸加成盐或酸加成盐的溶液： 其中 R1、R2、R3、R4、R5 和 R6 如上定义。
• METHOD FOR PRODUCING PYRAZOLECARBOXYLIC ACID DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：EP2687515A1

  公开（公告）日：2014-01-22

  Disclosed is a process for producing a pyrazole carboxylic acid derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor. A compound represented by the Formula (XI): is useful as a significant intermediate of an 11βHSD-1 inhibitor, wherein R1 and R2 are each independently hydrogen or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl and R4 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl.

  本发明公开了一种吡唑羧酸衍生物的生产工艺，该衍生物可用作 11βHSD-1 抑制剂的重要中间体。 由式（XI）代表的化合物： 可用作 11βHSD-1 抑制剂的重要中间体、 其中 R1 和 R2 各自独立地为氢或取代或未取代的烷基，R3 为取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的芳基、取代或未取代的杂芳基或取代或未取代的杂环基，且 R4 是取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的芳基、取代或未取代的杂芳基或取代或未取代的杂环基。
• EP2604591
  申请人：——

  公开号：——

  公开（公告）日：——
• METHOD FOR PRODUCING PYRAZOLE CARBOXYLIC ACID DERIVATIVE
  申请人：Uenaka Masaaki

  公开号：US20140012013A1

  公开（公告）日：2014-01-09

  Disclosed is a process for producing a pyrazole carboxylic acid derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor. A compound represented by the Formula (XI): is useful as a significant intermediate of an 11βHSD-1 inhibitor, wherein R 1 and R 2 are each independently hydrogen or substituted or unsubstituted alkyl, R 3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl and R 4 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl.
• US8901316B2
  申请人：——

  公开号：US8901316B2

  公开（公告）日：2014-12-02