4,5-二氢-2-[[2-异丙基-5-甲基苯氧基]甲基]-1H-咪唑单盐酸盐 | 28120-03-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 4,5-二氢-2-[[2-异丙基-5-甲基苯氧基]甲基]-1H-咪唑单盐酸盐
• 中文别名: 3-氨基-5-(氨基磺基基)-4-苯氧基苯甲酸；盐酸泰马唑啉
• 英文名称: hydrochloride salt of tymazoline
• 英文别名: Hydrochlorid v. 2-(Thymoloxymethyl)-imidazolin；2-(2-isopropyl-5-methyl-phenoxymethyl)-4,5-dihydro-1H-imidazole; hydrochloride；2-(2-Isopropyl-5-methyl-phenoxymethyl)-4,5-dihydro-1H-imidazol; Hydrochlorid；4,5-dihydro-2-[(2-isopropyl-5-methylphenoxy)methyl]-1H-imidazole monohydrochloride；Tymazoline hydrochloride；2-[(5-methyl-2-propan-2-ylphenoxy)methyl]-4,5-dihydro-1H-imidazole;hydrochloride
• CAS: 28120-03-8
• 化学式: C₁₄H₂₀N₂O*ClH
• 分子量: 268.787
• InChiKey: DKIDQLUKAZZLAR-UHFFFAOYSA-N

物化性质

• 熔点：
  >220°C (dec.)
• 溶解度：
  可溶于氯仿（轻微）、甲醇（（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  -1.52
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933290090

制备方法与用途

Tymazoline, known by the trade name Thymazen in Poland, is a nasal decongestant used to treat rhinitis. It functions as both an antihistamine and a sympathomimetic, helping to reduce swelling, inflammation, and mucosal secretions.

反应信息

• 作为产物：
  描述：

  2-isopropyl-5-methylphenoxyacetate 、 乙二胺 生成 4,5-二氢-2-[[2-异丙基-5-甲基苯氧基]甲基]-1H-咪唑单盐酸盐
  参考文献：
  名称：

  KALICKI, W.;ARTUNG, A.

  摘要：

  DOI：

文献信息

• An otorhinological drug delivery device
  申请人：Schering Oy

  公开号：EP1438942A1

  公开（公告）日：2004-07-21

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的芯体，其中所述芯体由弹性体组合物制成，该弹性体组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元S原子上的3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧烷）基团）及其混合物组成的组。
• Compositions and methods for the treatment of pain
  申请人：GM Pharmaceuticals, Inc.

  公开号：US10987365B2

  公开（公告）日：2021-04-27

  The claimed invention relates to compositions that may be in a form of a liquid, solid, gel, cream or gel capsule comprising an analgesic, and methods for administering these compositions for treatment of patients suffering from various forms of pain.

  本发明涉及可为液体、固体、凝胶、乳膏或凝胶胶囊形式的包含镇痛剂的组合物，以及使用这些组合物治疗各种形式疼痛患者的方法。
• PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF
  申请人：Pediamed Pharmaceuticals, Inc.

  公开号：EP1641446A1

  公开（公告）日：2006-04-05
• Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof
  申请人：PediaMed Pharmaceuticals, Inc.

  公开号：US20040259809A1

  公开（公告）日：2004-12-23

  The present invention provides pharmaceutical compositions including a sedating antihistamine and a stimulant, and methods of use thereof. The stimulant reduces the sedation caused by the antihistamine, thereby allowing potent, but sedating, antihistamines to be used effectively.
• PERSONALIZED PHARMACEUTICAL KITS, PACKAGING AND COMPOSITIONS FOR THE TREATMENT OF ALLERGIC CONDITIONS
  申请人：Du Jie

  公开号：US20090325999A1

  公开（公告）日：2009-12-31

  This invention relates to personalized pharmaceutical kits, packaging, compositions, and methods for treatment of a mammal, comprising at least one antihistamine for treating an allergic disease or condition in a mammal, in combination with at least one wakefulness promoting agent for preventing sedative effects during day time use, while promoting the antihistamine and sedating effect during evening use.