(E)-4-{(4S,6S)-6-[(2S,5R,6R)-8-(2,2-Dimethyl-propionyloxy)-5-methyl-2,6-bis-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-but-2-enoic acid methyl ester | 672906-52-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (E)-4-{(4S,6S)-6-[(2S,5R,6R)-8-(2,2-Dimethyl-propionyloxy)-5-methyl-2,6-bis-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-but-2-enoic acid methyl ester
• CAS: 672906-52-4
• 化学式: C₄₅H₅₈F₆O₁₂
• 分子量: 904.939
• InChiKey: MRNLXZXILGMTBI-HYEBFMPYSA-N

反应信息

• 作为反应物：
  描述：

  (E)-4-{(4S,6S)-6-[(2S,5R,6R)-8-(2,2-Dimethyl-propionyloxy)-5-methyl-2,6-bis-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-but-2-enoic acid methyl ester 在 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 以0.1 mg的产率得到(E)-(5S,7S,9S,12R,13R)-15-(2,2-Dimethyl-propionyloxy)-5,7-dihydroxy-12-methyl-9,13-bis-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentadec-2-enoic acid methyl ester
  参考文献：
  名称：

  Absolute Stereochemistry of Immunosuppressive Macrolide Brasilinolide A and Its New Congener Brasilinolide C

  摘要：

  Brasilinolide A (2) is a 32-membered polyhydroxyl macrolide with immunosuppressive activity isolated from a pathogenic actinomycete, Nocardia brasiliensis IFM0406. The absolute configurations at 26 chiral centers of 2 and its new congener, brasilinolide C (1), were determined on the basis of the spectral data of 1 and degradation products derived from 1 and degration products derived from 1and 2.

  DOI：

  10.1021/jo035773v
• 作为产物：
  描述：

  (E)-(5S,7R,9S,12R,13R)-15-(2,2-Dimethyl-propionyloxy)-5,7,9,13-tetrahydroxy-12-methyl-pentadec-2-enoic acid methyl ester 在 吡啶 、 4-二甲氨基吡啶 、 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 9.67h， 生成 (E)-4-{(4S,6S)-6-[(2S,5R,6R)-8-(2,2-Dimethyl-propionyloxy)-5-methyl-2,6-bis-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-but-2-enoic acid methyl ester
  参考文献：
  名称：

  Absolute Stereochemistry of Immunosuppressive Macrolide Brasilinolide A and Its New Congener Brasilinolide C

  摘要：

  Brasilinolide A (2) is a 32-membered polyhydroxyl macrolide with immunosuppressive activity isolated from a pathogenic actinomycete, Nocardia brasiliensis IFM0406. The absolute configurations at 26 chiral centers of 2 and its new congener, brasilinolide C (1), were determined on the basis of the spectral data of 1 and degradation products derived from 1 and degration products derived from 1and 2.

  DOI：

  10.1021/jo035773v