| 144067-20-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 144067-20-9
• 化学式: C₁₈H₂₆O₅
• 分子量: 322.401
• InChiKey: SPNPZFTZJFCIFK-DDLSDPMKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  61.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以76%的产率得到
  参考文献：
  名称：

  Partial synthesis of germacranolides with pyran and furan-type rings

  摘要：

  Pathways to synthesize germacranolides with ether bridges between C1 and C5 or C3 and C-10 were described. A joint precursor was prepared using a readily available and inexpensive compound as starting material. The key step in the preparation of dihydropyranone-germacranolides proved to be a one-pot procedure involving several transformations, induced by the iodotrimethylsilane/acetonitrile system.

  DOI：

  10.1016/s0040-4039(00)61275-3
• 作为产物：
  描述：

  [(3S,3aS,6Z,8Z,10E,11aS)-3,6,10-trimethyl-2-oxo-3a,4,5,11a-tetrahydro-3H-cyclodeca[b]furan-7-yl] acetate 在 氢氧化钾 、 对甲苯磺酸 作用下， 生成
  参考文献：
  名称：

  Partial synthesis of germacranolides with pyran and furan-type rings

  摘要：

  Pathways to synthesize germacranolides with ether bridges between C1 and C5 or C3 and C-10 were described. A joint precursor was prepared using a readily available and inexpensive compound as starting material. The key step in the preparation of dihydropyranone-germacranolides proved to be a one-pot procedure involving several transformations, induced by the iodotrimethylsilane/acetonitrile system.

  DOI：

  10.1016/s0040-4039(00)61275-3