(5-nitro-1H-indol-3-yl)-(4-propan-2-ylphenyl)methanol | 1415030-65-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (5-nitro-1H-indol-3-yl)-(4-propan-2-ylphenyl)methanol
• CAS: 1415030-65-7
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: GVEPMTDEVWGUCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-硝基吲哚 、 4-异丙基苯甲醛 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以30%的产率得到(5-nitro-1H-indol-3-yl)-(4-propan-2-ylphenyl)methanol
  参考文献：
  名称：

  Cesium carbonate mediated synthesis of 3-(α-hydroxyaryl)indoles

  摘要：

  A series of 3-(alpha-hydroxyaryl)indoles have been synthesized by the reaction of aromatic aldehydes with indoles, catalyzed by cesium carbonate in DMF medium. The reactivity of the various alkali metal carbonates is discussed. The stability of 3-(alpha-hydroxyaryl)indoles is also discussed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.002

文献信息

• Cesium carbonate mediated synthesis of 3-(α-hydroxyaryl)indoles
  作者：Rasokkiyam Elayaraja、R. Joel Karunakaran

  DOI：10.1016/j.tetlet.2012.10.002

  日期：2012.12

  A series of 3-(alpha-hydroxyaryl)indoles have been synthesized by the reaction of aromatic aldehydes with indoles, catalyzed by cesium carbonate in DMF medium. The reactivity of the various alkali metal carbonates is discussed. The stability of 3-(alpha-hydroxyaryl)indoles is also discussed. (C) 2012 Elsevier Ltd. All rights reserved.