(2E)-1-(2,5-dimethoxyphenyl)-3,7-dimethylocta-2,6-dien-1-ol | 1392835-87-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2E)-1-(2,5-dimethoxyphenyl)-3,7-dimethylocta-2,6-dien-1-ol
• CAS: 1392835-87-8
• 化学式: C₁₈H₂₆O₃
• 分子量: 290.403
• InChiKey: POJBTJLECOGVSR-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-溴-2,5-二甲氧基苯 、 柠檬醛 在 正丁基锂 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 、 (2E)-1-(2,5-dimethoxyphenyl)-3,7-dimethylocta-2,6-dien-1-ol
  参考文献：
  名称：

  Rapid synthesis of methoxyconidiol and conitriol stereoisomers

  摘要：

  We describe the diastereoselective synthesis of the marine meroterpenes methoxyconidiol and conitriol in their trans form from the readily available 1-bromo-2,5-dimethoxybenzene in only three steps. The choice of the protective group strategy influenced not only the overall reaction yields but also the diastereoisomeric ratio. In addition, we describe the synthesis of natural conitriol (cis form) for the first time. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.050

文献信息

• Rapid synthesis of methoxyconidiol and conitriol stereoisomers
  作者：Gérald Lopez、Anne Witczak、Christophe Menniti、Nicolas Inguimbert、Bernard Banaigs

  DOI：10.1016/j.tetlet.2012.06.050

  日期：2012.8

  We describe the diastereoselective synthesis of the marine meroterpenes methoxyconidiol and conitriol in their trans form from the readily available 1-bromo-2,5-dimethoxybenzene in only three steps. The choice of the protective group strategy influenced not only the overall reaction yields but also the diastereoisomeric ratio. In addition, we describe the synthesis of natural conitriol (cis form) for the first time. (C) 2012 Elsevier Ltd. All rights reserved.