N-[[1-[7-(diethylamino)-2-oxochromen-3-yl]triazol-4-yl]methyl]acetamide | 1393527-80-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-[[1-[7-(diethylamino)-2-oxochromen-3-yl]triazol-4-yl]methyl]acetamide
• CAS: 1393527-80-4
• 化学式: C₁₈H₂₁N₅O₃
• 分子量: 355.396
• InChiKey: ZTYJKUPVXYWAMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  89.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(2-丙炔基)乙酰胺 、 3-叠氮基-7-(二乙氨基)香豆素 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以49%的产率得到N-[[1-[7-(diethylamino)-2-oxochromen-3-yl]triazol-4-yl]methyl]acetamide
  参考文献：
  名称：

  Highly selective and sensitive fluorescence turn-on probe for a catalytic amount of Cu(I) ions in water through the click reaction

  摘要：

  A simple azide-functionalized coumarin (1) was utilized as a fluorescence turn-on probe for a catalytic amount of Cu(I) ions in HEPES buffer. The probe has shown a selective and sensitive response to the cuprous ions over other various cations through a Cu(I)-mediated click reaction of 1 to an alkyne. When a catalytic amount of copper sulfates was added in the presence of ascorbate, the prominent fluorescence 'Off-On' change of 1 was observed so that submicromolar concentration of copper ions was detectable by the naked eye. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.079

文献信息

• Highly selective and sensitive fluorescence turn-on probe for a catalytic amount of Cu(I) ions in water through the click reaction
  作者：Seokan Park、Hae-Jo Kim

  DOI：10.1016/j.tetlet.2012.06.079

  日期：2012.8

  A simple azide-functionalized coumarin (1) was utilized as a fluorescence turn-on probe for a catalytic amount of Cu(I) ions in HEPES buffer. The probe has shown a selective and sensitive response to the cuprous ions over other various cations through a Cu(I)-mediated click reaction of 1 to an alkyne. When a catalytic amount of copper sulfates was added in the presence of ascorbate, the prominent fluorescence 'Off-On' change of 1 was observed so that submicromolar concentration of copper ions was detectable by the naked eye. (C) 2012 Elsevier Ltd. All rights reserved.