tert-Butyl-diphenyl-[6-phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-ynyloxy]-silane | 192506-63-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-Butyl-diphenyl-[6-phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-ynyloxy]-silane
• CAS: 192506-63-1
• 化学式: C₅₆H₆₂O₇Si
• 分子量: 875.19
• InChiKey: FAFDPYJQEBBHJO-NOJFGURRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.91
• 重原子数：
  64.0
• 可旋转键数：
  20.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  64.61
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  tert-Butyl-diphenyl-[6-phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-ynyloxy]-silane 在 4-二甲氨基吡啶 、 重铬酸吡啶 、 四丁基氟化铵 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 6-Phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-ynoic acid (3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester
  参考文献：
  名称：

  New glycosylation reaction based on alkyne-Co2(CO)6 complex

  摘要：

  O-Protected glycopyranoside possessing 4-(O-protected-glucosyl)-6-phenyl-5-hexynoate residue at anomeric position was converted into the corresponding cobalt complex, which on exposure to trimethylsilyl trifluoromethanesulfonate afforded glucosylglucoside derivative in a good yield via internal delivery of glycosyl acceptor. Similar O-protected galactopyranoside and mannopyranoside derivatives provided the corresponding galactosylglucoside and mannosylglucoside derivative, respectively. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00983-0
• 作为产物：
  描述：

  甲基2,3,4-三-O-苄基-α-D-吡喃葡萄糖苷 、 6-{[tert-Butyl(diphenyl)silyl]oxy}-1-phenylhex-1-yn-3-ol 在 dicobalt octacarbonyl 、 ammonium cerium(IV) nitrate 、 三氟化硼乙醚 作用下， 生成 tert-Butyl-diphenyl-[6-phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-ynyloxy]-silane
  参考文献：
  名称：

  New glycosylation reaction based on alkyne-Co2(CO)6 complex

  摘要：

  O-Protected glycopyranoside possessing 4-(O-protected-glucosyl)-6-phenyl-5-hexynoate residue at anomeric position was converted into the corresponding cobalt complex, which on exposure to trimethylsilyl trifluoromethanesulfonate afforded glucosylglucoside derivative in a good yield via internal delivery of glycosyl acceptor. Similar O-protected galactopyranoside and mannopyranoside derivatives provided the corresponding galactosylglucoside and mannosylglucoside derivative, respectively. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00983-0