dinorbornylphosphine chloride | 1198229-10-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: dinorbornylphosphine chloride
• 英文别名: Bis(2-bicyclo[2.2.1]heptanyl)-chlorophosphane；bis(2-bicyclo[2.2.1]heptanyl)-chlorophosphane
• CAS: 1198229-10-5
• 化学式: C₁₄H₂₂ClP
• 分子量: 256.755
• InChiKey: QNLRRJFYOZVULZ-UHFFFAOYSA-N

物化性质

• 沸点：
  329.8±9.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dinorbornylphosphine chloride 、 N,N'-bis(o-bromophenyl)thiourea 在 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 13.0h， 以82%的产率得到
  参考文献：
  名称：

  一种硫脲型氮膦配体及其制备方法和应用

  摘要：

  本发明提供一种硫脲型氮膦配体及其制备方法和应用，所述配体的结构式为该硫脲型氮膦配体以芳胺和芳基异硫氰酸酯反应得到芳基硫脲，再与二取代膦反应得到。所得硫脲型氮膦配体可用于1,3‑丁二烯与亲核体的调聚反应，不但大幅降低金属催化剂的用量，并且转化率高、选择性好。

  公开号：

  CN113620990B

文献信息

• ChenPhos: Highly Modular P-Stereogenic<i>C</i>₁-Symmetric Diphosphine Ligands for the Efficient Asymmetric Hydrogenation of α-Substituted Cinnamic Acids
  作者：Weiping Chen、Felix Spindler、Benoit Pugin、Ulrike Nettekoven

  DOI：10.1002/anie.201304472

  日期：2013.8.12

  cats are purrfectionists: The ChenPhos ligands (see structure) showed dramatically higher catalytic activity in the title reaction than their C2‐symmetric predecessor with two dimethylaminoethyl‐substituted ferrocenyl(phenyl)phosphanyl groups. The ready accessibility, extreme air stability, and high enantioselectivity, activity, and productivity of these ligands make them very promising for a wide range

  这些猫是纯粹主义者：ChenPhos配体（参见结构）在标题反应中比其带有两个二甲基氨基乙基取代的二茂铁基（苯基）膦酰基的C 2对称对称异构体显示出更高的催化活性。这些配体易于获得，极高的空气稳定性以及高对映选择性，活性和生产率，使它们在广泛的实际应用中非常有前途。
• METHOD FOR PREPARING HALOGENATED ORGANOPHOSPHINES
  申请人：Zavorine Serguei I.

  公开号：US20110071319A1

  公开（公告）日：2011-03-24

  The present application relates to a process for preparing a halogenated organophosphine, comprising reacting a primary or secondary organophosphine with a halogenating agent selected from (A) a compound of formula (I): (HaI) 3 C—C(O)—X (I) wherein X is selected from alkyl, aryl, aralkyl, alkaryl, cycloalkyl, NR 1 R 2 , C(HaI) 3 , OR 3 , -0—C(O)—R 3′ , or —Y—Z—Y—C(O)—C(HaI) 3 ; R1 and R2 are each independently selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, or cycloalkyl; R3 is selected from H, alkyl, aryl, aralkyl, alkaryl, cycloalkyl, or triorganosilyl; R 3′ is selected from C(HaI) 3 , alkyl, aryl, aralkyl, alkaryl, cycloalkyl; Y is independently selected from 0 or NH; Z is independently selected from alkylene, arylene, aralkylene, alkarylene, or cycloakylene; and Hal is selected from Cl or Br; or (B) a derivative of a polyol, polyamine or polyaminoalcohol comprising two or more hydroxyl and/or amino groups, in which a hydrogen atom in each of the hydroxyl and/or amino groups is replaced with a group —C(O)—C(HaI) 3 , wherein Hal is selected from Cl or Br.

  本申请涉及一种制备卤代有机膦的方法，包括将一种一级或二级有机膦与一种卤化试剂反应，所述卤化试剂选自以下组合物：（A）式（I）的化合物：（HaI）3C—C（O）—X（I），其中X选自烷基、芳基、芳基烷基、烷芳基、环烷基、NR1R2、C（HaI）3、OR3、-0—C（O）—R3'或—Y—Z—Y—C（HaI）3；R1和R2各自独立地选自氢、烷基、芳基、芳基烷基、烷芳基或环烷基；R3选自H、烷基、芳基、芳基烷基、烷芳基、环烷基或三有机硅基；R3'选自C（HaI）3、烷基、芳基、芳基烷基、烷芳基或环烷基；Y各自独立地选自0或NH；Z各自独立地选自烷基、芳基、芳基烷基、烷芳基或环烷基；Hal选自Cl或Br；或（B）一种多元醇、多胺或多胺醇的衍生物，其中包含两个或两个以上的羟基和/或氨基团，其中每个羟基和/或氨基团中的一个氢原子被一个基团—C（O）—C（HaI）3所取代，其中Hal选自Cl或Br。
• [EN] METHOD FOR PREPARING HALOGENATED ORGANOPHOSPHINES<br/>[FR] PROCÉDÉ POUR LA FABRICATION D'ORGANOPHOSPHINES HALOGÉNÉES
  申请人：CYTEC CANADA INC

  公开号：WO2009147495A2

  公开（公告）日：2009-12-10

  The present application relates to a process for preparing a halogenated organophosphine, comprising reacting a primary or secondary organophosphine with a halogenating agent selected from (A) a compound of formula (I) : (HaI)3C-C(O)-X (I) wherein X is selected from alkyl, aryl, aralkyl, alkaryl, cycloalkyl, NR1R2, C(HaI)3, OR3, -0-C(O)-R3', or -Y-Z-Y-C(O)- C(HaI)3; R1 and R2 are each independently selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, or cycloalkyl; R3 is selected from H, alkyl, aryl, aralkyl, alkaryl, cycloalkyl, or triorganosilyl; R3' is selected from C(HaI)3, alkyl, aryl, aralkyl, alkaryl, cycloalkyl; Y is independently selected from 0 or NH; Z is independently selected from alkylene, arylene, aralkylene, alkarylene, or cycloakylene; and Hal is selected from Cl or Br; or (B) a derivative of a polyol, polyamine or polyaminoalcohol comprising two or more hydroxyl and/or amino groups, in which a hydrogen atom in each of the hydroxyl and/or amino groups is replaced with a group -C(O)-C(HaI)3, wherein Hal is selected from Cl or Br.
• 一种硫脲型氮膦配体及其制备方法和应用
  申请人：万华化学集团股份有限公司

  公开号：CN113620990B

  公开（公告）日：2022-11-08

  本发明提供一种硫脲型氮膦配体及其制备方法和应用，所述配体的结构式为该硫脲型氮膦配体以芳胺和芳基异硫氰酸酯反应得到芳基硫脲，再与二取代膦反应得到。所得硫脲型氮膦配体可用于1,3‑丁二烯与亲核体的调聚反应，不但大幅降低金属催化剂的用量，并且转化率高、选择性好。