(1R*,3aS*,7aR*)-Hexahydro-3a-methyl-7-methylene-1-indanacetic Acid | 139017-55-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R*,3aS*,7aR*)-Hexahydro-3a-methyl-7-methylene-1-indanacetic Acid
• 英文别名: (1R^*,3aS^*,7aR^*)-Hexahydro-3a-methyl-7-methylene-1-indanacetic Acid
• CAS: 139017-55-3
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: HTTHJWHKCVFQEO-WCFLWFBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.23
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 (1R*,3aS*,7aR*)-Hexahydro-3a-methyl-7-methylene-1-indanacetic Acid 、 丙酮 生成 Methyl (αR*,1S*,3aS*,7aR*)-Hexahydro-α-(1-hydroxy-1-methylethyl)-3a-methyl-7-methylene-1-indanacetate 、 Methyl (αR*,1R*,3aR*,7aS*)-Hexahydro-α-(1-hydroxy-1-methylethyl)-3a-methyl-7-methylene-1-indanacetate
  参考文献：
  名称：

  Synthetic approaches to the axane family of sesquiterpenoids. Total synthesis of (dl)-axamide-4, (dl)-axisonitrile-4, and (dl)-axisothiocyanate-4

  摘要：

  Two methods for the preparation of perhydroindan 7 are described. One involves an intramolecular free radical cyclization in a key step and proceeds in 13 steps and 9% yield from anisole (9). The other involves an intramolecular conjugate addition mediated by pyrrolidine (28 --> 7) and proceeds in five steps and 30% overall yield from vinylogous ester 29. Two unsuccessful attempts to convert 7 into axane sesquiterpenoids 1-6 are described. The synthesis of axanes 4-6 was achieved using a potassium tert-butoxide catalyzed cyclization of a dienoic keto ester as a key step (47 + 48 --> 49). Conversion of alpha,beta-unsaturated ester 49 to vinyl isocyanate 57 was accomplished using a Curtius rearrangement and reduction of 57 with lithium triethylborohydride completed the synthesis of axamide-4 (4). The preparation of axisonitrile-4 (5) and axisothiocyanate-4 (6) from 4 is also described.

  DOI：

  10.1021/jo00033a023
• 作为产物：
  描述：

  Ethyl (1R*,3aS*,7aR*)-Hexahydro-3a-methyl-7-methylene-1-indanacetate 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以84%的产率得到(1R*,3aS*,7aR*)-Hexahydro-3a-methyl-7-methylene-1-indanacetic Acid
  参考文献：
  名称：

  Synthetic approaches to the axane family of sesquiterpenoids. Total synthesis of (dl)-axamide-4, (dl)-axisonitrile-4, and (dl)-axisothiocyanate-4

  摘要：

  Two methods for the preparation of perhydroindan 7 are described. One involves an intramolecular free radical cyclization in a key step and proceeds in 13 steps and 9% yield from anisole (9). The other involves an intramolecular conjugate addition mediated by pyrrolidine (28 --> 7) and proceeds in five steps and 30% overall yield from vinylogous ester 29. Two unsuccessful attempts to convert 7 into axane sesquiterpenoids 1-6 are described. The synthesis of axanes 4-6 was achieved using a potassium tert-butoxide catalyzed cyclization of a dienoic keto ester as a key step (47 + 48 --> 49). Conversion of alpha,beta-unsaturated ester 49 to vinyl isocyanate 57 was accomplished using a Curtius rearrangement and reduction of 57 with lithium triethylborohydride completed the synthesis of axamide-4 (4). The preparation of axisonitrile-4 (5) and axisothiocyanate-4 (6) from 4 is also described.

  DOI：

  10.1021/jo00033a023