1-(2-chloro-7-methoxyquinolin-3-yl)-N-(3-fluorophenyl)methanimine | 1122022-22-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2-chloro-7-methoxyquinolin-3-yl)-N-(3-fluorophenyl)methanimine
• CAS: 1122022-22-3
• 化学式: C₁₇H₁₂ClFN₂O
• 分子量: 314.746
• InChiKey: LIIZUKCQUDGADM-UHFFFAOYSA-N

物化性质

• 熔点：
  148-150 °C
• 沸点：
  481.9±45.0 °C(predicted)
• 密度：
  1.26±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-chloro-7-methoxyquinolin-3-yl)-N-(3-fluorophenyl)methanimine 、 亚磷酸三乙酯 在 三甲基氯硅烷 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以93.3%的产率得到diethyl (3-fluorophenylamino)(2-chloro-7-methoxyquinolin-3-yl)methylphosphonate
  参考文献：
  名称：

  Simple and High Yielding Synthesis of New α-Aminophosphonates from Imines

  摘要：

  A simple and high yielding method was developed for the synthesis of novel alpha-aminophosphonates from imines, obtained from 2-chloroquinoline-3-carbaldehyde, by using triethylphosphite in the presence of chlorotrimethylsilane (TMSCl). This method developed for the synthesis of -aminophosphonates gave excellent yields.

  DOI：

  10.1080/10426500701681532
• 作为产物：
  描述：

  3-氟苯胺 、 2-氯-7-甲氧基喹啉-3-甲醛 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 0.42h， 以96.2%的产率得到1-(2-chloro-7-methoxyquinolin-3-yl)-N-(3-fluorophenyl)methanimine
  参考文献：
  名称：

  Simple and High Yielding Synthesis of New α-Aminophosphonates from Imines

  摘要：

  A simple and high yielding method was developed for the synthesis of novel alpha-aminophosphonates from imines, obtained from 2-chloroquinoline-3-carbaldehyde, by using triethylphosphite in the presence of chlorotrimethylsilane (TMSCl). This method developed for the synthesis of -aminophosphonates gave excellent yields.

  DOI：

  10.1080/10426500701681532

文献信息

• Simple and High Yielding Synthesis of New α-Aminophosphonates from Imines
  作者：Rajkumar U. Pokalwar、Rajkumar V. Hangarge、Balaji R. Madje、Madhav N. Ware、Murlidhar S. Shingare

  DOI：10.1080/10426500701681532

  日期：2008.5.14

  A simple and high yielding method was developed for the synthesis of novel alpha-aminophosphonates from imines, obtained from 2-chloroquinoline-3-carbaldehyde, by using triethylphosphite in the presence of chlorotrimethylsilane (TMSCl). This method developed for the synthesis of -aminophosphonates gave excellent yields.