(1R,2S,4S)-2-isopropyl-4-methylcyclohexan-3,4,6-tri-O-benzyl-β-Dmannopyranoside | 768368-83-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,2S,4S)-2-isopropyl-4-methylcyclohexan-3,4,6-tri-O-benzyl-β-Dmannopyranoside
• 英文别名: (1R,2S,5R)-menthyl 3,4,6-tri-O-benzyl-β-D-mannopyranoside
• CAS: 768368-83-8
• 化学式: C₃₇H₄₈O₆
• 分子量: 588.785
• InChiKey: SDOKOQNRRQRYSZ-MKEQEWDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.94
• 重原子数：
  43.0
• 可旋转键数：
  13.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  66.38
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (1R,2S,4S)-2-isopropyl-4-methylcyclohexan-3,4,6-tri-O-benzyl-β-Dmannopyranoside 在 palladium on activated charcoal 吡啶 、 氢气 作用下， 以 乙醇 为溶剂， 生成 (1R,2S,5R)-menthyl 2,3,4,6-tetra-O-(p-bromobenzoyl)-β-D-mannopyranoside
  参考文献：
  名称：

  Experimental evidence on the hydroxymethyl group conformation in alkyl β-d-mannopyranosides

  摘要：

  A rotational population Study of the hydroxymethyl group of alkyl beta-D-mannopyranosides was performed by means of CD and NMR spectroscopy. Three different benzyl, acetyl, and p-bromobenzoyl series of alkyl beta-D-mannopyranosides with different chiral and nonchiral aglycons were synthesized and analyzed. Different rotational populations were observed for each series by changing the structure of the aglycon. The results showed a clear correlation between the rotational population of the hydroxymethyl group around the C5-C6 bond and the pK(a) of the bonded alcohol (aglycon). The population of the gt rotamer gradually increased as the pK(a) increased while that of the gg rotamer decreased and the population of the tg rotamer remained almost constant. This is explained by the exo-anomeric effect. For chiral alkyl derivatives, the results also showed a close dependence on the absolute configuration of the aglycon. Comparison of rotational population anomers revealed the dependence or the hydroxymethyl group on the anomeric configuration and a greater dependence on the aglycon structure in the beta anomers. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.06.019
• 作为产物：
  描述：

  phenyl 2-O-[((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)dimethylsilane]-3,4,6-tri-O-benzyl-1-thio-α-D-mannopyranoside 在 N-碘代丁二酰亚胺 、 2,6-二叔丁基-4-甲基吡啶 、 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 以98%的产率得到(1R,2S,4S)-2-isopropyl-4-methylcyclohexan-3,4,6-tri-O-benzyl-β-Dmannopyranoside
  参考文献：
  名称：

  Sugar silanes: versatile reagents for stereocontrolled glycosylation via intramolecular aglycone delivery

  摘要：

  描述了一种用于醇的分子内糖基化的新方法。

  DOI：

  10.1039/c5sc00810g

文献信息

• Buchan, Zachary A.; Bader, Scott J.; Montgomery, John, Angewandte Chemie - International Edition, 2009, vol. 48, p. 4840 - 4844
  作者：Buchan, Zachary A.、Bader, Scott J.、Montgomery, John

  DOI：——

  日期：——