(18S)-18-hydroxydammar-21-ene | 20078-64-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (18S)-18-hydroxydammar-21-ene
• 英文别名: (2S)-6-methyl-2-[(5S,8R,9R,10S,13R,14R,17S)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-5-en-2-ol
• CAS: 20078-64-2
• 化学式: C₃₀H₅₂O
• 分子量: 428.742
• InChiKey: ZGYAWGWSDGHMHA-GKLUMWEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (18S)-18-hydroxydammar-21-ene 在 chromium(VI) oxide 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 以108 mg的产率得到(S)-5-Methyl-5-((5S,8R,9R,10S,13R,14R,17S)-4,4,8,10,14-pentamethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-dihydro-furan-2-one
  参考文献：
  名称：

  Dammarane triterpenoids from rhizomes of Pyrrosia lingua

  摘要：

  Hexane extract of fresh rhizomes of Pyrroisa lingua (Thunb.) Farwell. yielded five new dammarane triterpenoids, designated as octanordammarane (1), (18S)-18-hydroxydammar-21-ene (3), (18S)-pyrrosialactone (5), (18S)-pyrrosialactol (7) and 3-deoxyocotillol (8), along with known dammara-18(28),21-diene (2). Structures of 1, 3, 5, 7 and 8 were elucidated by mainly 2D NMR and other spectroscopic analyses and chemical correlations. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(98)00303-3
• 作为产物：
  描述：

  20S-hydroxydammar-24-ene-3,12-dione 在 氢氧化钾 、 一水合肼 作用下， 以 二乙二醇 为溶剂， 生成 (18S)-18-hydroxydammar-21-ene
  参考文献：
  名称：

  Tanaka,O. et al., Chemical and pharmaceutical bulletin, 1972, vol. 20, p. 1204 - 1211

  摘要：

  DOI：

文献信息

• Tanaka,O. et al., Chemical and pharmaceutical bulletin, 1972, vol. 20, p. 1204 - 1211
  作者：Tanaka,O. et al.

  DOI：——

  日期：——
• Dammarane triterpenoids from rhizomes of Pyrrosia lingua
  作者：Hiroshi Yamashita、Kazuo Masuda、Tomomi Kobayashi、Hiroyuki Ageta、Keniji Shiojima

  DOI：10.1016/s0031-9422(98)00303-3

  日期：1998.12

  Hexane extract of fresh rhizomes of Pyrroisa lingua (Thunb.) Farwell. yielded five new dammarane triterpenoids, designated as octanordammarane (1), (18S)-18-hydroxydammar-21-ene (3), (18S)-pyrrosialactone (5), (18S)-pyrrosialactol (7) and 3-deoxyocotillol (8), along with known dammara-18(28),21-diene (2). Structures of 1, 3, 5, 7 and 8 were elucidated by mainly 2D NMR and other spectroscopic analyses and chemical correlations. (C) 1998 Elsevier Science Ltd. All rights reserved.