3β-hydroxyolean-12-en-11-one acetate | 107657-18-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β-hydroxyolean-12-en-11-one acetate
• 英文别名: 11-oxo-β-amyrin acetate；3β-Acetoxy-12-oleanen-11-one；beta-Amyrenonol acetate；[(3S,4aR,6aR,6bS,8aR,12aR,14aR,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl] acetate
• CAS: 107657-18-1；5356-56-9
• 化学式: C₃₂H₅₀O₃
• 分子量: 482.747
• InChiKey: SOINDUWJQBFDIH-BJFAYYBWSA-N

物化性质

• 沸点：
  536.5±49.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  35
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3β-hydroxyolean-12-en-11-one acetate 在 氢氧化钾 作用下， 生成 beta-香树脂酮醇
  参考文献：
  名称：

  Long-term glycemic control measurements in diabetic patients receiving hemodialysis

  摘要：

  Cardiovascular morbidity is increased in patients with diabetes mellitus and there is a great prevalence of diabetes and cardiovascular disease among patients with end-stage renal disease (ESRD). Control of glycemia can decrease cardiovascular and end-organ damage. Because the validity of glycemic control tests have not been rigorously studied in patients with ESRD, we evaluated the value of various measures in these patients. The overall clinical goal was to investigate whether hemoglobin A(1)C (A(1)C) accurately reflects actual glycemic control as compared with other measures in light of the importance of attaining appropriately controlled blood glucose (BG). The commonly used tests of total glycated hemoglobin (GHb) and A(1)C may be unreliable in patients with ESRD because of the presence of anemia, shortened red blood cell (RBC) survival, and assay interferences from uremia. The primary aim of this study was to assess the relationship of capillary BG measurements to A(1)C, GHb, total glycated plasma proteins (GPP), and fructosamine (Fr) in diabetic patients receiving hemodialysis. Twenty-three patients were instructed to obtain BG evaluations twice daily for 7 days by using the Elite glucometer (Bayer Corporation, Elkhart, IN). These determinations included 6 fasting, 6 preprandial, and 3 separate 2-hour postprandial levels. Blood was obtained on day 7 for measurement of A(1)C, GHb, GPP, and Fr. A(1)C was analyzed by an immunoassay, GPP and GHb were assayed by affinity high-performance liquid chromatography (HPLC), and Fr by automated nitroblue colorimetric assay. Scatter plots were generated by plotting the average BG versus A(1)C, GHb, GPP, or Fr. Linear regression was performed for each plot showing the following relationships: A(1)C = 0.0174 (BG) + 4.76 (r = 0.58; P < 0.05): GHb = 0.0371 (BG) + 3.57 (r = 0.584; P < 0.05): GPP = 0.0083 (BG) + 26.13 (r = 0.065; P = 0.77): Fr = 0.6865 (BG) + 250 (r = 0.345; P = 0.11). Despite anemia and shortened RBC lifespan in patients with ESRD, A(1)C in the range of 6% to 7% estimates glycemic control similarly to patients without severe renal impairment. A(1)C values above 7.5% may overestimate hyperglycemia in patients with ESRD. Thus, diabetic patients receiving hemodialysis may have long-term BG that are more properly controlled than previously determined, reducing their risks of the macro- and microvascular complications of diabetes mellitus. (C) 2002 by the National Kidney Foundation, Inc.

  DOI：

  10.1053/ajkd.2002.30549
• 作为产物：
  描述：

  3β-Benzoyloxyolean-12-en-11-on 在 吡啶 、 氢氧化钾 、 苯 作用下， 生成 3β-hydroxyolean-12-en-11-one acetate
  参考文献：
  名称：

  225.三萜烯树脂醇和相关酸。第十部分β-淀粉丁烯醇

  摘要：

  DOI：

  10.1039/jr9400001198

文献信息

• Barton, Derek H. R.; Boivin, Jean; Hill, Christopher H., Journal of the Chemical Society. Perkin transactions I, 1986, p. 1797 - 1804
  作者：Barton, Derek H. R.、Boivin, Jean、Hill, Christopher H.

  DOI：——

  日期：——
• Chauhan; Mohapatra; Mamta, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 3, p. 183 - 189
  作者：Chauhan、Mohapatra、Mamta、Parkash、Azam

  DOI：——

  日期：——
• Über die Amyrine
  作者：H. Dieterle、H. Braß、F. Schaal

  DOI：10.1002/ardp.19372750802

  日期：——
• Terpenoids of Canarium zeylanicum
  作者：Wickramasinghe M. Bandaranayake

  DOI：10.1016/s0031-9422(00)81969-x

  日期：1980.1
• Allan et al., Journal of the Chemical Society, 1956, p. 456,463
  作者：Allan et al.

  DOI：——

  日期：——