BOC-RS-2-氨基辛二酸 | 292642-79-6

• 物质功能分类: 生物化工 - 生化试剂 - 氨基酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: BOC-RS-2-氨基辛二酸
• 英文名称: 2-(tert-butoxycarbonylamino)octanedioic acid
• 英文别名: Boc-DL-asu-oh；2-[(2-methylpropan-2-yl)oxycarbonylamino]octanedioic acid
• CAS: 292642-79-6
• 化学式: C₁₃H₂₃NO₆
• 分子量: 289.329
• InChiKey: WZVLJRPOVUCTFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  BOC-RS-2-氨基辛二酸 在 盐酸 、 4-(4,6-二甲氧基三嗪-2-基)-4-甲基吗啉盐酸盐 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 25.0h， 生成 1,8-bis(dodecylamino)-1,8-dioxooctan-2-aminium chloride
  参考文献：
  名称：

  Controlling the Position of Functional Groups at the Liquid/Solid Interface: Impact of Molecular Symmetry and Chirality

  摘要：

  With the aim of controlling the position of functional groups in a substrate-supported monolayer, a new family of functionalized linear alkyl chains was designed and synthesized, aided by molecular mechanics and dynamics simulations of its two-dimensional self-assembly on graphite. The self-assembly of these amino functionalized diamides at the liquid/solid interface was investigated with scanning tunneling microscopy. Intermolecular hydrogen-bonding interactions involving amides, combined with the effect of molecular symmetry and chirality, were found to guide the self-assembly. Control of the relative position and orientation of the amine groups was achieved, in the case of enantiopure compounds. Interestingly, racemates led to both racemic conglomerate and solid solution formation, with a concomitant loss of positional and orientational control of the amino groups as a result.

  DOI：

  10.1021/ja209018u
• 作为产物：
  描述：

  2-amino-octanedioic acid 、 二碳酸二叔丁酯 在 三乙胺 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以95%的产率得到BOC-RS-2-氨基辛二酸
  参考文献：
  名称：

  Controlling the Position of Functional Groups at the Liquid/Solid Interface: Impact of Molecular Symmetry and Chirality

  摘要：

  With the aim of controlling the position of functional groups in a substrate-supported monolayer, a new family of functionalized linear alkyl chains was designed and synthesized, aided by molecular mechanics and dynamics simulations of its two-dimensional self-assembly on graphite. The self-assembly of these amino functionalized diamides at the liquid/solid interface was investigated with scanning tunneling microscopy. Intermolecular hydrogen-bonding interactions involving amides, combined with the effect of molecular symmetry and chirality, were found to guide the self-assembly. Control of the relative position and orientation of the amine groups was achieved, in the case of enantiopure compounds. Interestingly, racemates led to both racemic conglomerate and solid solution formation, with a concomitant loss of positional and orientational control of the amino groups as a result.

  DOI：

  10.1021/ja209018u

文献信息

• [EN] FEM1B PROTEIN BINDING AGENTS AND USES THEREOF<br/>[FR] AGENTS SE LIANT À LA PROTÉINE FEM1B ET UTILISATIONS ASSOCIÉES
  申请人：UNIV CALIFORNIA

  公开号：WO2021183431A1

  公开（公告）日：2021-09-16

  Disclosed herein, inter alia, are compounds for binding FEMIB protein and uses thereof. In an aspect, provided herein is a pharmaceutical composition including a compound as described herein and a pharmaceutically acceptable excipient.

  本文披露了用于结合FEMIB蛋白的化合物及其用途。在一个方面，本文提供了一种包括本文描述的化合物和药用可接受的赋形剂的药物组合物。
• [EN] BETA-ADRENERGIC RECEPTOR ALLOSTERIC MODULATORS<br/>[FR] MODULATEURS ALLOSTÉRIQUES DE RÉCEPTEURS BÊTA-ADRÉNERGIQUES
  申请人：UNIV CALIFORNIA

  公开号：WO2019204768A1

  公开（公告）日：2019-10-24

  Provided herein are modulators of beta-adrenergic receptors.

  这里提供了β肾上腺素受体的调节剂。
• [EN] INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE<br/>[FR] INHIBITEURS DE L'INTÉGRINE ALPHA 2 BÊTA 1 ET PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2019178248A1

  公开（公告）日：2019-09-19

  Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.

  本文披露了抑制整合素α2β1的方法，以及使用这些方法的方法。
• [EN] STABILIZATION OF MHC COMPLEXES<br/>[FR] STABILISATION DE COMPLEXES CMH
  申请人：UNIV CALIFORNIA

  公开号：WO2021133742A1

  公开（公告）日：2021-07-01

  Provided, inter alia, are methods and compositions for treating cancer.

  提供了治疗癌症的方法和组合物，包括但不限于。
• [EN] COMPOSITIONS AND METHODS FOR MODULATING PROTEASE ACTIVITY<br/>[FR] COMPOSITIONS ET MÉTHODES POUR MODULER L'ACTIVITÉ PROTÉASE
  申请人：UNIV CALIFORNIA

  公开号：WO2018097999A1

  公开（公告）日：2018-05-31

  Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.

  本文披露了用于调节蛋白酶活性和治疗癌症的组合物。