24,25,26,27-tetranor-3β-acetoxycycloartan-23-ol | 1073193-87-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 24,25,26,27-tetranor-3β-acetoxycycloartan-23-ol
• 英文别名: [(1S,3R,6S,8R,11S,12S,15R,16R)-15-[(2R)-4-hydroxybutan-2-yl]-7,7,12,16-tetramethyl-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] acetate
• CAS: 1073193-87-9
• 化学式: C₂₈H₄₆O₃
• 分子量: 430.671
• InChiKey: GRAACLNUVVLDPG-YGYXNBHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  24,25,26,27-tetranor-3β-acetoxycycloartan-23-ol 、 乙酸酐 在 吡啶 作用下， 生成
  参考文献：
  名称：

  Terpenoid metabolites from the aerial part of Artemisia lagocephala

  摘要：

  Six naturally occurring terpenoids were isolated from the hexane extract of rabbit-head wormwood Artemisia lagocephala (Fisch. ex Besser) DC. The terpenoids' structures were elucidated by spectroscopic and chemical methods as 3 beta-acetoxycycloartan-24-ozonide (1), 3 beta-acetoxycycloartan-24-al (2), 25,26,27-trisnor-3 beta-acetoxycycloartan-24-ol (3), 24,25,26,27-tetranor-3 beta-acetoxycycloartan-23-ol (4), and the previously known caryophyllene oxide (5) and (1R,4S)-p-menth-2-en-1-ol (6). (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.phytol.2011.11.006

文献信息

• MODULATORS OF AMYLOID-BETA PRODUCTION
  申请人：Findeis Mark A.

  公开号：US20100056487A1

  公开（公告）日：2010-03-04

  As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.

  本发明提供了用于治疗或减轻神经退行性疾病的化合物。本发明还提供了治疗或减轻此类疾病的方法，其中该方法包括向患者施用本发明的化合物或其组合物。该方法适用于治疗或减轻例如阿尔茨海默病等疾病的严重程度。