H-Aminomalonsaeure-aminomalonsaeure | 14811-62-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Aminomalonsaeure-aminomalonsaeure
• 英文别名: 2-[(2-Amino-2-carboxyacetyl)amino]propanedioic acid
• CAS: 14811-62-2
• 化学式: C₆H₈N₂O₇
• 分子量: 220.139
• InChiKey: MBVRRBLDDWFVTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  167
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Composition and method for providing localized delivery of a therapeutic agent
  申请人：Gemeinhart Richard A.

  公开号：US20080131510A1

  公开（公告）日：2008-06-05

  The present invention is a composition for providing localized delivery of a therapeutic agent to a subject. The instant composition is a hydrophilic matrix-based prodrug system, wherein a protease substrate peptide acts as extracellular protease degradable spacer binding the therapeutic agent to a hydrophilic matrix. Release of the therapeutic agent is achieved by localized activity of extracellular proteases thereby providing minimal toxicity of the therapeutic agent and maximum release with protease activity. Methods for producing the instant composition and providing localized delivery of a therapeutic agent to a subject are also provided.
• US7943569B2
  申请人：——

  公开号：US7943569B2

  公开（公告）日：2011-05-17