2,3-(methylenedioxy)-5-ethyl-7-hydroxy-8-methoxy-benzo[c]phenanthridinium hydrogen sulfate | 143201-33-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: 2,3-(methylenedioxy)-5-ethyl-7-hydroxy-8-methoxy-benzo[c]phenanthridinium hydrogen sulfate
• 英文别名: 12-Ethyl-2-methoxy-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium-1-ol;hydrogen sulfate
• CAS: 143201-33-6
• 化学式: C₂₁H₁₈NO₄*H*O₄S
• 分子量: 445.45
• InChiKey: RPCHQGDMSZVGOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.67
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Process for preparing benzo[C]phenanthridinium derivatives, and novel compounds prepared by said process
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0487930A1

  公开（公告）日：1992-06-03

  The present invention relates to a process for preparing benzo[c]phenanthridinium derivatives of the general formula A: wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X⁻ represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group. This process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. Also, it has been found that certain novel benzo[c]phenanthridinium derivatives, prepared by the present process, have not only an antitumor activity but also an inhibition activity on blood platelet aggregation. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating into phamaceutical preparations.

  本发明涉及一种制备通式 A 的苯并[c]菲啶鎓衍生物的工艺： 其中 M 和 N 分别代表羟基或低级烷氧基，或 M 和 N 同时代表氢原子或共同形成亚甲基二氧基，X- 代表酸残基或氢酸残基，R 代表低级烷基。该工艺具有良好的重现性，可在中等条件下进行，因此该工艺非常实用。此外，还发现通过本工艺制备的某些新型苯并[c]菲啶衍生物不仅具有抗肿瘤活性，还具有抑制血小板聚集的活性。此外，本发明化合物的氢盐具有更高的稳定性，这在配制成医药制剂方面具有优势。
• Benzo[C]phenanthridinium derivatives
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0487930B1

  公开（公告）日：1999-03-24
• NOVEL 9-N-BICYCLIC NUCLEOSIDE AGENTS USEFUL AS SELECTIVE INHIBITORS OF PROINFLAMMATORY CYTOKINES
  申请人：MERRELL PHARMACEUTICALS INC.

  公开号：EP0710239B1

  公开（公告）日：1999-02-10
• US5747502A
  申请人：——

  公开号：US5747502A

  公开（公告）日：1998-05-05