7-oxo-3,4-seco-cholestene-(5)-dioic acid-(3,4) | 911444-65-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-oxo-3,4-seco-cholestene-(5)-dioic acid-(3,4)
• 英文别名: 7-Oxo-3,4-seco-cholesten-(5)-disaeure-(3,4)
• CAS: 911444-65-0
• 化学式: C₂₇H₄₂O₅
• 分子量: 446.627
• InChiKey: WXPIXBVTJYHALZ-KZYYWDDLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.97
• 重原子数：
  32.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  91.67
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  7-oxo-3,4-seco-cholestene-(5)-dioic acid-(3,4) 在 硫酸 、 溶剂黄146 、 锌 作用下， 生成 7-oxo-3,4-seco-5α-cholestanedioic acid-(3,4)-3-methyl ester
  参考文献：
  名称：

  Windaus, Chemische Berichte, 1908, vol. 41, p. 611,614

  摘要：

  DOI：
• 作为产物：
  描述：

  cholesterol 在 氢氧化钾 、 potassium permanganate 、 sodium dichromate 、 溶剂黄146 作用下， 生成 7-oxo-3,4-seco-cholestene-(5)-dioic acid-(3,4)
  参考文献：
  名称：

  Cholesterol and Companions. II. Exhaustive Dichromate Oxidation

  摘要：

  DOI：

  10.1021/ja01114a002

文献信息

• Ultrastructural Localisation of Sialoadhesin (Siglec- 1) on Macrophages in Rodent Lymphoid Tissues
  作者：Inge L. Schadee-Eestermans、Elizabeth C.M. Hoefsmit、Marja Van De Ende、Paul R. Crocker、Timo K. Van Den Berg

  DOI：10.1016/s0171-2985(00)80036-4

  日期：2000.11

  In previous studies it has been demonstrated that sialoadhesin is a macrophage-restricted adhesion receptor for lymphocytes and myeloid cells. It is under normal circumstances expressed by subpopulations of macrophages in lymphoid and haemopoietic tissues. In this study different immunoelectronmicroscopical techniques are used to investigate the ultrastructural localisation of sialoadhesin within the lymph node and spleen of rodents. The results show that sialoadhesin is selectively expressed by a subset of macrophages in peripheral lymphoid tissues. Sialoadhesin was localised predominantly on the plasma membrane and in particular in areas of intimate contact with lymphocytes, thereby visualizing putative local interaction between these cells. Interestingly, sialoadhesin was also detected in intracellular vesicles that were apparently taken up by macrophages. These findings are consistent with the putative role of sialoadhesin in local cell-cell interactions in lymphoid tissues. Surprisingly, sialoadhesin was also found at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells, suggesting that sialoadhesin also mediates interactions with these cell types.
• Butenandt; Schramm, Chemische Berichte, 1936, vol. 69, p. 2289,2295
  作者：Butenandt、Schramm

  DOI：——

  日期：——
• Windaus, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1932, vol. 213, p. 147,158, 159
  作者：Windaus

  DOI：——

  日期：——
• Auditory Model Enhances Relative-Timing Learning
  作者：Qin Lai、Charles H. Shea、Lisa Bruechert、Mark Little

  DOI：10.1080/00222890209601948

  日期：2002.9

  In recent experiments (Q. Lai, C. H. Shea, & M. Little, 2000; C. H. Shea, G. Wulf, J. Park, & B. Gaunt, 2001), auditory models were found to be effective in enhancing relative-timing performance and learning in constant practice conditions. In the present experiment, the authors examined (a) whether an auditory model also enhances relative-timing learning in blocked and random practice conditions and (b) whether experience with the auditory model enhances participants' ability to produce the response by using different effector sequences. Participants (N = 48) were randomly assigned to 1 of 4 acquisition conditions in which an auditory model was or was not present and the practice schedule was blocked or random. In the acquisition phase, all participants alternately pressed 2 keys on a keyboard in an attempt to match 5 goal intervals. In the auditory model conditions, a sequence of tones was played before each acquisition trial. The tones represented the correct timing sequence for that trial. One retention and 3 effector-transfer tests without feedback were administered about 24 hr after the completion of acquisition. The results indicated that the auditory model enhanced relative-timing performance and learning independently of practice schedule. In addition, the auditory model enhanced relative timing on the effector-transfer tests, but absolute-timing performance and learning were not affected by the auditory model. Thus, relative timing was found to be effector independent but absolute timing was not.