(4,8-dichloroquinolin-3-yl)(phenyl)methanone | 127448-36-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (4,8-dichloroquinolin-3-yl)(phenyl)methanone
• 英文别名: (4,8-dichloroquinolin-3-yl)-phenylmethanone
• CAS: 127448-36-6
• 化学式: C₁₆H₉Cl₂NO
• 分子量: 302.16
• InChiKey: APODFZNSLKAGNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.77
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.96
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (4,8-dichloroquinolin-3-yl)(phenyl)methanone 在 四(三苯基膦)钯 三乙酰氧基硼氢化钠 、 sodium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙醇 、 水 、 甲苯 为溶剂， 反应 3.0h， 生成 [4-({[3-(3-benzoyl-8-chloroquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid
  参考文献：
  名称：

  Further modification on phenyl acetic acid based quinolines as liver X receptor modulators

  摘要：

  A series of phenyl acetic acid based quinolines was prepared as LXR modulators. An SAR study in which the C-3 and C-8 positions of the quinoline core were varied led to the identification of two potent LXR agonists 23 and 27. Both compounds displayed good binding affinity for LXR beta and LXR alpha, and increased expression of ABCAl in THP-1 cells. These two compounds also had desirable pharmacokinetic profiles in mice and displayed in vivo efficacy in a 12-week Apo E knockout mouse lesion model. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.03.013
• 作为产物：
  描述：

  (Z)-2-(苯甲酰基)-3-乙氧基丙-2-烯酸乙酯 、 邻氯苯胺 在 diphenyl ether-biphenyl eutectic 、 三氯氧磷 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以72%的产率得到(4,8-dichloroquinolin-3-yl)(phenyl)methanone
  参考文献：
  名称：

  Further modification on phenyl acetic acid based quinolines as liver X receptor modulators

  摘要：

  A series of phenyl acetic acid based quinolines was prepared as LXR modulators. An SAR study in which the C-3 and C-8 positions of the quinoline core were varied led to the identification of two potent LXR agonists 23 and 27. Both compounds displayed good binding affinity for LXR beta and LXR alpha, and increased expression of ABCAl in THP-1 cells. These two compounds also had desirable pharmacokinetic profiles in mice and displayed in vivo efficacy in a 12-week Apo E knockout mouse lesion model. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.03.013

文献信息

• MENDES, ETIENNE;VERNIERES, JEAN-CLAUDE;KEANE, PETER EUGENE;BACHY, ANDRE
  作者：MENDES, ETIENNE、VERNIERES, JEAN-CLAUDE、KEANE, PETER EUGENE、BACHY, ANDRE

  DOI：——

  日期：——