<3S-(3α,3aα,9aα,9bβ)>-1,2,3,3a,4,6,8,9,9a,9b-Decahydro-3a-methylspiro<7H-benzinden-7,2'-<1,3>dioxolan>-3-ol | 98483-41-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: <3S-(3α,3aα,9aα,9bβ)>-1,2,3,3a,4,6,8,9,9a,9b-Decahydro-3a-methylspiro<7H-benzinden-7,2'-<1,3>dioxolan>-3-ol
• CAS: 98483-41-1
• 化学式: C₁₆H₂₄O₃
• 分子量: 264.365
• InChiKey: FABQEUVOGFESCE-QPSCCSFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.64
• 重原子数：
  19.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  <3S-(3α,3aα,9aα,9bβ)>-1,2,3,3a,4,6,8,9,9a,9b-Decahydro-3a-methylspiro<7H-benzinden-7,2'-<1,3>dioxolan>-3-ol 在 lithium aluminium tetrahydride 、 重铬酸吡啶 、 对甲苯磺酸 、 lithium diisopropyl amide 作用下， 以 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 4.83h， 生成 (2R,3S,3aS,9aS,9bS)-2-Ethyl-3-hydroxy-3a-methyl-1,2,3,3a,4,5,8,9,9a,9b-decahydro-cyclopenta[a]naphthalen-7-one
  参考文献：
  名称：

  Antiandrogenic activity of a series of des-A-steroid derivatives

  摘要：

  In the search for new antiandrogens, a number of des-A-steroids were prepared by condensation of Grignard reagents with lactone 3. From the resulting key intermediates 5, various structural modifications were performed such as the introduction of an additional unsaturation to afford dienones 8 and aromatic derivatives 10 or the introduction of an alkyl substituent mostly in position 10 (11-13) but also in some cases in position 16 (22). In addition, 13-ethyl analogues were also prepared from lactone 4. The relative binding affinities (RBAs) for the androgen receptor of these compounds were determined under various conditions. Some compounds exhibit a capacity to interact with the receptor comparable to that of testosterone. One of the most potent compounds is 17beta-hydroxy-des-A-androsta-9,11-dien-5-one (8b), RBA value 73% of that of testosterone. More interestingly, several compounds were found to have an antiandrogenic profile in vitro and in vivo. One of the most effective compounds is 10-ethyl-17beta-hydroxy-des-A-estra-9-en-5-one (5c), which exhibits a strong local antiandrogenic activity in hamsters, without any significant systemic antiandrogenic effects. The corresponding 17beta-acetyl derivative (RU 38882) has been selected for extended pharmacological studies.

  DOI：

  10.1021/jm00150a009
• 作为产物：
  描述：

  Acetic acid (3S,3aS,9aS,9bS)-3a-methyl-7-oxo-2,3,3a,4,5,7,8,9,9a,9b-decahydro-1H-cyclopenta[a]naphthalen-3-yl ester 在 氢氧化钾 、 对甲苯磺酸 作用下， 以 甲醇 、 苯 为溶剂， 反应 5.0h， 生成 <3S-(3α,3aα,9aα,9bβ)>-1,2,3,3a,4,6,8,9,9a,9b-Decahydro-3a-methylspiro<7H-benzinden-7,2'-<1,3>dioxolan>-3-ol
  参考文献：
  名称：

  Antiandrogenic activity of a series of des-A-steroid derivatives

  摘要：

  In the search for new antiandrogens, a number of des-A-steroids were prepared by condensation of Grignard reagents with lactone 3. From the resulting key intermediates 5, various structural modifications were performed such as the introduction of an additional unsaturation to afford dienones 8 and aromatic derivatives 10 or the introduction of an alkyl substituent mostly in position 10 (11-13) but also in some cases in position 16 (22). In addition, 13-ethyl analogues were also prepared from lactone 4. The relative binding affinities (RBAs) for the androgen receptor of these compounds were determined under various conditions. Some compounds exhibit a capacity to interact with the receptor comparable to that of testosterone. One of the most potent compounds is 17beta-hydroxy-des-A-androsta-9,11-dien-5-one (8b), RBA value 73% of that of testosterone. More interestingly, several compounds were found to have an antiandrogenic profile in vitro and in vivo. One of the most effective compounds is 10-ethyl-17beta-hydroxy-des-A-estra-9-en-5-one (5c), which exhibits a strong local antiandrogenic activity in hamsters, without any significant systemic antiandrogenic effects. The corresponding 17beta-acetyl derivative (RU 38882) has been selected for extended pharmacological studies.

  DOI：

  10.1021/jm00150a009

文献信息

• Neurosteroid Analogs. 2. Total Synthesis and Electrophysiological Evaluation of Benz[e]indene Analogs of the Anesthetic Steroid Alphaxalone
  作者：Yuefei Hu、Charles F. Zorumski、Douglas F. Covey

  DOI：10.1021/jo00117a010

  日期：1995.6

  Anesthetic steroid Pa and benz[e]indene 2 are known to have potent pharmacological actions at GABA(A) receptors. Anesthetic Il-ketosteroids such as alfaxalone (Ph) are also known to have this activity. Evaluation of corresponding 5H-benz[e]inden-5-one analogs of Il-ketosteroids necessitated the development of an efficient route to these compounds. Accordingly, total synthesis of the 5H-benz[e]inden-5-ones 3 and 4 from the known 5H-inden-5-one precursor 5 is described. The structure of compound 3 has been verified by X-ray diffraction analysis. Electrophysiological evaluations of compounds 3 and 4 indicate that, unlike benz[e]indene 2, these compounds have weak pharmacological actions at GABA(A) receptors.