8-methoxy-7-methyl-quinoline | 815576-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-methoxy-7-methyl-quinoline
• 英文别名: 8-methoxy-7-methylquinoline
• CAS: 815576-13-7
• 化学式: C₁₁H₁₁NO
• 分子量: 173.214
• InChiKey: HQYPCFKTJJSRHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-2,2'-二碘-1,1'-联萘 、 8-methoxy-7-methyl-quinoline 在 叔丁基锂 作用下， 以 四氢呋喃 为溶剂， 以81%的产率得到
  参考文献：
  名称：

  系链双(8-羟基喹啉)铝配合物催化醛亚胺和酮亚胺的双活化不对称Strecker反应

  摘要：

  发现铝配合物对于将氰化物添加到醛亚胺和酮亚胺中具有高产率和对映选择性。尽管过去已经广泛研究了将氰化物催化不对称加成到亚胺以生成 α-氨基保护的腈（Strecker 反应），但现代有机合成需要用于该过程的替代性、更易于处理的试剂。迄今为止，在这一重要反应中使用除 KCN/HCN 或 TMSCN 之外的其他氰化物来源的报告数量有限。本催化剂使用氰基甲酸乙酯作为氰化物源为芳族、杂芳族和脂族醛亚胺和酮亚胺提供均匀的高对映选择性。

  DOI：

  10.1021/ja907268g
• 作为产物：
  描述：

  7-diethylaminomethyl-8-hydroxyquinoline 在 palladium on activated charcoal 氢氧化钾 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 18.0h， 生成 8-methoxy-7-methyl-quinoline
  参考文献：
  名称：

  Origins of ‘on–off’ fluorescent behavior of 8-hydroxyquinoline containing chemosensors

  摘要：

  Derivatives of 8-hydroxyquinoline were used as model compounds to probe the pathways of non-radiative relaxation of fluorophores in two fluorescent chemosensors. Results suggest that both photo-induced proton transfer and photo-induced electron transfer contribute to quenching the fluorescence of the chemosensors. Crystal structures of an 8-hydroxyquinoline-containing chemosensor complexed to various metal ions indicate that a proton shift occurs concomitant with complex formation. This proton shift precludes both photo-induced proton and electron transfer allowing fluorescence emission from chemosensor-metal ion complexes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.062

文献信息

• [EN] SPIROPIPERIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE SPIROPIPÉRIDINE
  申请人：CEPHALON INC

  公开号：WO2018112204A1

  公开（公告）日：2018-06-21

  Described herein are spiropiperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described spiropiperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described spiropiperidine compounds and synthetic intermediates that are useful in those syntheses.

  本文所述的是根据式I的螺哌啶化合物，它们已显示出作为脂肪酸合成酶抑制剂的活性。本文还描述了含有所述螺哌啶化合物的药物组合物，以及通过施用本文所述的一种或多种化合物或药物制剂来治疗由脂肪酸合成酶介导的疾病的方法。本文还描述了合成所述化合物的方法，包括所述螺哌啶化合物及其在那些合成中有用的合成中间体。
• [EN] ZIRCONIUM CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS<br/>[FR] COMPLEXE CONTENANT DU ZIRCONIUM ET CATALYSEURS DE RÉACTION DE CONDENSATION, PROCÉDÉS POUR PRÉPARER CES CATALYSEURS ET COMPOSITIONS CONTENANT CES CATALYSEURS
  申请人：DOW CORNING

  公开号：WO2013036548A2

  公开（公告）日：2013-03-14

  A composition is capable of curing via condensation reaction. The composition uses a new condensation reaction catalyst. The new condensation reaction catalyst is used to replace conventional tin catalysts. The composition can react to form a gum, gel, rubber, or resin.
• Dual-Activation Asymmetric Strecker Reaction of Aldimines and Ketimines Catalyzed by a Tethered Bis(8-quinolinolato) Aluminum Complex
  作者：Joshua P. Abell、Hisashi Yamamoto

  DOI：10.1021/ja907268g

  日期：2009.10.28

  aldimines and ketimines. Although catalytic asymmetric addition of cyanide to imines to generate alpha-amino-protected nitriles (the Strecker reaction) has been extensively studied in the past, alternative, easier-to-handle reagents for this process are required for modern organic synthesis. To date, there are a limited number of reports utilizing alternative sources of cyanide other than KCN/HCN or TMSCN

  发现铝配合物对于将氰化物添加到醛亚胺和酮亚胺中具有高产率和对映选择性。尽管过去已经广泛研究了将氰化物催化不对称加成到亚胺以生成 α-氨基保护的腈（Strecker 反应），但现代有机合成需要用于该过程的替代性、更易于处理的试剂。迄今为止，在这一重要反应中使用除 KCN/HCN 或 TMSCN 之外的其他氰化物来源的报告数量有限。本催化剂使用氰基甲酸乙酯作为氰化物源为芳族、杂芳族和脂族醛亚胺和酮亚胺提供均匀的高对映选择性。
• Origins of ‘on–off’ fluorescent behavior of 8-hydroxyquinoline containing chemosensors
  作者：R. Todd Bronson、Marco Montalti、Luca Prodi、Nelsi Zaccheroni、Randy D. Lamb、N. Kent Dalley、Reed M. Izatt、Jerald S. Bradshaw、Paul B. Savage

  DOI：10.1016/j.tet.2004.08.062

  日期：2004.11

  Derivatives of 8-hydroxyquinoline were used as model compounds to probe the pathways of non-radiative relaxation of fluorophores in two fluorescent chemosensors. Results suggest that both photo-induced proton transfer and photo-induced electron transfer contribute to quenching the fluorescence of the chemosensors. Crystal structures of an 8-hydroxyquinoline-containing chemosensor complexed to various metal ions indicate that a proton shift occurs concomitant with complex formation. This proton shift precludes both photo-induced proton and electron transfer allowing fluorescence emission from chemosensor-metal ion complexes. (C) 2004 Elsevier Ltd. All rights reserved.