methyl 1-N-acetamido-2,3,4-tri-O-acetyl-β-D-glucuronate | 314079-48-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 1-N-acetamido-2,3,4-tri-O-acetyl-β-D-glucuronate
• CAS: 314079-48-6
• 化学式: C₁₅H₂₁NO₁₀
• 分子量: 375.332
• InChiKey: BHWWPCKSSTVNQR-PDWCTOEPSA-N

物化性质

• 沸点：
  490.8±45.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.18
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  143.53
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  methyl 1-N-acetamido-2,3,4-tri-O-acetyl-β-D-glucuronate 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 0.5h， 以52%的产率得到N-(β-D-glucuronopyranosyl)acetamide
  参考文献：
  名称：

  Synthesis of N-(β-d-glycuronopyranosyl)alkanamides and 1-(β-d-glycuronopyranosyl)-4-phenyl-[1,2,3]-triazoles as N-glycoprotein linkage region analogs: examination of the effect of C5 substituent on the N-glycosidic torsion (ΦN) based on X-ray crystallography

  摘要：

  The torsion angle around the N-glycoprotein linkage region (GlcNAc-Asn) is an important factor for presenting sugar on the cell surface which is crucial for many biological processes. Earlier studies using model and analogs showed that this important torsion angle is greatly influenced by substitutions in the sugar part. In the present work, uronic acid alkanamides and triazole derivatives have been designed and synthesized as newer analogs of N-glycoprotein linkage region to understand the influence of the carboxylic group on linkage region torsion as well as on molecular packing. Crystal structure of N-(beta-D-galacturonopyranosyl)acetamide is solved with the space group of P22(1)2(1). Comparison of the torsion angle and molecular packing of this compound with N-(beta-D-galactopyranosyl)acetamide showed that changing the C6-hydoxymethyl group to the carboxylic acid group has minimum influence on the N-glycosidic torsion angle, Phi(N) and significant influence on the molecular packing. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2013.06.023
• 作为产物：
  描述：

  D-GLUCURONIDEMETHYLESTERD-葡糖苷酸甲酯 在 palladium on activated charcoal 吡啶 、 sodium azide 、 高氯酸 、 氢溴酸 、 氢气 、 四丁基硫酸氢铵 作用下， 以 二氯甲烷 、 碳酸氢钠 、 溶剂黄146 、 乙酸乙酯 为溶剂， 反应 2.0h， 生成 methyl 1-N-acetamido-2,3,4-tri-O-acetyl-β-D-glucuronate
  参考文献：
  名称：

  Rapid access to uronic acid-based mimetics of Kdn2en from d-glucurono-6,3-lactone

  摘要：

  A concise route to novel mimetics of Kdn2en, based on Delta(4)-uronic acids, from D-glucurono-6,3-lactone is presented. Uronic acid-based mimetics in which an aliphatic ether (O-glycoside), a thioether (S-glycoside), or acetamide takes the place of the natural C-6 glycerol sidechain of the sialic acid were synthesized from the key intermediate, methyl 2,3,4-tri-O-acetyl-alpha-D-glucopyranosyluronate bromide. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(00)00228-7