3-isopropyl-2,4,6-trimethylaniline | 104666-00-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-isopropyl-2,4,6-trimethylaniline
• 英文别名: Isopropylmesidin；2,4,6-Trimethyl-3-propan-2-ylaniline
• CAS: 104666-00-4
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: KNIOSDLPJBTECB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Isopropenylmesidin 在 platinum(IV) oxide 氢气 作用下， 以 溶剂黄146 为溶剂， 生成 3-isopropyl-2,4,6-trimethylaniline
  参考文献：
  名称：

  Restricted Rotation in Aryl Amines. XXII. Effect of meta Substitution on the Optical Stability of Some N-Benzenesulfonyl-N-carboxymethylmesidines

  摘要：

  DOI：

  10.1021/ja01472a031

文献信息

• Efficient Synthesis of Sterically Hindered Arenes Bearing Acyclic Secondary Alkyl Groups by Suzuki-Miyaura Cross-Couplings
  作者：Chengxi Li、Tianyu Chen、Bowen Li、Guolan Xiao、Wenjun Tang

  DOI：10.1002/anie.201411518

  日期：2015.3.16

  Bulky P,PO ligands were designed to inhibit isomerization and reduction side reactions during the cross coupling between sterically hindered aryl halides and alkylboronic acids. Suzuki–Miyaura cross‐couplings between di‐ortho‐substituted aryl bromides and acyclic secondary alkylboronic acids have been achieved with high yields. The method has also enabled the preparation of ortho‐alkoxy di‐ortho‐substituted

  庞大的P，P = O配体设计用于在位阻芳基卤化物和烷基硼酸之间的交叉偶联过程中抑制异构化和还原副反应。高产率地实现了二邻位取代的芳基溴化物和无环仲烷基硼酸之间的Suzuki-Miyaura交叉偶联。该方法还能够以优异的收率制备带有异丙基的邻烷氧基双邻取代芳烃。合成方法的实用性已在雌酮的后期修饰中以及在向棉酚的新合成途径中的应用中得到了证明。
• TRANSCRIPTIONALLY TARGETED AND CPG-FREE PLASMID FOR THERANOSTIC GENE THERAPY
  申请人：The Johns Hopkins University

  公开号：US20200140831A1

  公开（公告）日：2020-05-07

  A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for non-viral gene therapy to treat cancer, including hepatocellular carcinoma and prostate cancer.
• NONVIRAL GENE TRANSFER TO THE SUPRACHOROIDAL SPACE
  申请人：The Johns Hopkins University

  公开号：US20200330396A1

  公开（公告）日：2020-10-22

  The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.
• GENE DELIVERY PARTICLES TO INDUCE TUMOR-DERIVED ANTIGEN PRESENTING CELLS
  申请人：The Johns Hopkins University

  公开号：US20220154219A1

  公开（公告）日：2022-05-19

  Synthetic, biodegradable nanoparticles (NPs) encapsulating at least one of a signal 1 protein, a signal 2 protein, and/or a signal 3 protein are disclosed, which, when transfected into one or more a cancer cells, reprogram the one or more cancer cells into “tumor-derived APCs” in vivo to activate T-cells and natural killer (NK) cells for systemic tumor rejection. The NPs can be used for treating cancers, in particular metastatic cancers.
• US9884118B2
  申请人：——

  公开号：US9884118B2

  公开（公告）日：2018-02-06