4-氨基-2-丙基喹啉 | 57165-80-7

• 物质功能分类: 医药中间体 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-氨基-2-丙基喹啉
• 英文名称: 2-propyl-[4]quinolylamine
• 英文别名: 2-Propyl-[4]chinolylamin；2-Propylquinolin-4-amine
• CAS: 57165-80-7
• 化学式: C₁₂H₁₄N₂
• 分子量: 186.257
• InChiKey: AIARCVIPBFNMEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S26,S39
• 危险类别码：
  R22,R41
• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  2-propyl-quinoline-4-carboxylic acid amide 生成 4-氨基-2-丙基喹啉
  参考文献：
  名称：

  Austin et al., Journal of Pharmacy and Pharmacology, 1959, vol. 11, p. 80,86

  摘要：

  DOI：

文献信息

• Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
  申请人：Dickson K. John

  公开号：US20060009460A1

  公开（公告）日：2006-01-12

  Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

  本发明公开了基于喹啉和异喹啉的化合物，展现出ATP利用酶抑制活性，公开了使用展现出ATP利用酶抑制活性的化合物的方法，并公开了包含展现出ATP利用酶抑制活性的化合物的组合物。
• Method for predicting skin sensitizing activity of compounds
  申请人：Dickson, JR. John K.

  公开号：US20090069338A1

  公开（公告）日：2009-03-12

  Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

  本发明揭示了基于喹啉和异喹啉的化合物，这些化合物表现出ATP利用酶抑制活性，以及使用表现出ATP利用酶抑制活性的化合物的方法和包含表现出ATP利用酶抑制活性的化合物的组合物。
• Dihydro-1,4-oxazino(2,3-c)quinolines, a process and intermediates for the preparation thereof and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0299345A2

  公开（公告）日：1989-01-18

  The present application relates to compounds of the formula I where X is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, nitro or trifluoromethyl; R₁ is hydrogen or loweralkyl; R₂ is hydrogen, loweralkyl, arylloweralkyl or -(CH₂)mR₇ wherein m is 1, 2 or 3 and R₇ is cyano or amino; R₃ and R₄ are independently hydrogen or loweralkyl; R₅ and R₆ are independently hydrogen or loweralkyl, or R₅+R₆ taken together with the carbon atom to which they are attached constitute a cyclobutane, cyclopentane, cyclohexane, cycloheptane, pyrrolidine, piperidine, morpholine or thiomorpholine ring, or R₅ is hydrogen and R₆ is aryl or -CH₂OR₈ wherein R₈ is hydrogen, loweralkyl or loweralkylcarbonyl, which are useful for enhancing memory. and a process for their preparation. The invention relates also to compounds of the formula II where X, R₁ and R₃ through R₆ are as defined earlier and R₉ is hydrogen or bromine (with the proviso that when R₁=R₃=R₄=R₅=R₆=R₉=H, X is not 7-chloro) which are also useful for enhancing memory and for preparing compounds of formula I.

  本申请涉及式 I 的化合物 其中 X 是氢、低级烷基、低级烷氧基、羟基、卤素、硝基或三氟甲基；R₁ 是氢或低级烷基；R₂ 是氢、低级烷基、芳基低级烷基或-(CH₂)mR₇，其中 m 是 1、2 或 3，R₇ 是氰基或氨基；R₃ 和 R₄ 独立地是氢或低级烷基；R₅ 和 R₆ 独立地为氢或低级烷基，或 R₅+R₆ 与它们所连接的碳原子一起构成环丁烷、环戊烷、环己烷、环庚烷吡咯烷、哌啶、吗啉或硫代吗啉环，或 R₅ 为氢且 R₆ 为芳基或 -CH₂OR₈ 其中 R₈ 为氢、低级烷基或低级烷基羰基。及其制备工艺。 本发明还涉及式 II 的化合物 其中 X、R₁ 和 R₃ 至 R₆ 如前定义，R₉ 是氢或溴 (但当 R₁=R₃=R₄=R₅=R₆=R₉=H 时，X 不是 7-氯)，这些化合物也有助于增强记忆力和制备式 I 的化合物。
• Bone Modulators And Methods Therewith
  申请人：Espina Virginia

  公开号：US20120065166A1

  公开（公告）日：2012-03-15

  THE INVENTION RELATES TO compositions, compounds, proteins and methods of treatment therewith. Aspects of embodiments also relate to a method of treating a patient by delivering to the tissues of said patient or administering to said patient a therapeutically effective amount of one or more compounds. Aspects of embodiments also relate to a method of detecting the presence of bone disease by machine-assaying detectable serotonin. Aspects of embodiments also relate to methods of treating disease in subjects.
• US4743601A
  申请人：——

  公开号：US4743601A

  公开（公告）日：1988-05-10