9-iodo-3-methyl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one | 332359-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-iodo-3-methyl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one
• CAS: 332359-28-1
• 化学式: C₁₄H₁₄INO
• 分子量: 339.176
• InChiKey: JRBRLDSKKFBODR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-iodo-3-methyl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 在 氢氧化钾 、 copper(l) iodide 、 sodium hydride 作用下， 以 1,4-二氧六环 、 二甲基亚砜 为溶剂， 反应 5.5h， 生成 2-(1-(4-methoxybenzyl)-3-methyl-2-oxo-1,2,3,4,5,6-hexahydrobenzo[h]quinolin-9-yl)malonic acid diethyl ester
  参考文献：
  名称：

  Synthesis and study of a heterocyclic receptor designed for carboxylic acids

  摘要：

  The synthesis of a tricyclic receptor having a bowl shape and three binding points for carboxylic acids has been achieved starting from readily available 1-tetralone derivatives according to two different methods. This host possesses a six-membered lactam moiety and a carboxamide at the end of a flexible arm. Association constant with benzoic acid and stoichiometry of the complex have been determined using H-1 NMR dilution experiments. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2004.03.045
• 作为产物：
  描述：

  7-溴-3,4-二氢萘-1(2H)-酮 在 正丁基锂 、 正硅酸甲酯 、 叔丁基锂 、 cesium fluoride 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 9-iodo-3-methyl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one
  参考文献：
  名称：

  Synthesis and study of a heterocyclic receptor designed for carboxylic acids

  摘要：

  The synthesis of a tricyclic receptor having a bowl shape and three binding points for carboxylic acids has been achieved starting from readily available 1-tetralone derivatives according to two different methods. This host possesses a six-membered lactam moiety and a carboxamide at the end of a flexible arm. Association constant with benzoic acid and stoichiometry of the complex have been determined using H-1 NMR dilution experiments. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2004.03.045

文献信息

• Synthesis of a heterocyclic receptor for carboxylic acids
  作者：Gregory Moore、Vincent Levacher、Jean Bourguignon、Georges Dupas

  DOI：10.1016/s0040-4039(00)01934-1

  日期：2001.1

  The synthesis of a tricyclic receptor having a bowl shape and three binding points for carboxylic acids has been achieved starting from readily available 1-tetralone derivatives. This host possesses a six-membered lactam moiety and a carboxamide at the end of a flexible arm. The association constant with benzoic acid and the stoichiometry of the complex have been determined using H-1 NMR dilution experiments. (C) 2000 Elsevier Science Ltd. All rights reserved.