7-methyl undecan-5-ol-6-one | 134840-22-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-methyl undecan-5-ol-6-one
• 英文别名: (5S,7R)-5-hydroxy-7-methylundecan-6-one
• CAS: 134840-22-5
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: JVSWFAFLPXELPK-MNOVXSKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-fluoro undec-6-ene 5-ol (Z) 在 titanium(IV) isopropylate 、 叔丁基过氧化氢 、 ammonium hydroxide 、 L-(+)-酒石酸二异丙酯 、 3 A molecular sieve 、 氯化铵 、 iron(II) sulfate 、 酒石酸 作用下， 反应 25.33h， 生成 7-methyl undecan-5-ol-6-one
  参考文献：
  名称：

  Asymmetric epoxidation of fujorinated allylic alcohols

  摘要：

  The asymmetric epoxidation of an alpha, beta-difluoro primary allylic alcohol, and of two alpha-fluoro secondary allylic alcohols follows the pattern known with non fluorinated analogs. The fluoro epoxides thus formed can be transformed into chiral alpha-ketols and into an alpha-fluoroacid.

  DOI：

  10.1016/s0957-4166(00)82361-7

文献信息

• Spirodiepoxide Reaction with Cuprates
  作者：Partha Ghosh、Stephen D. Lotesta、Lawrence J. Williams

  DOI：10.1021/ja068813w

  日期：2007.3.1

  The first example of transition-metal-mediated transformations of spirodiepoxides and the first general method for carbon-carbon bond formation using the spirodiepoxide functional group are reported. Organocopper-mediated addition to spirodiepoxides gives direct access to densely functionalized hydroxy ketones. The process establishes two noncontiguous stereocenters and installs two oxygen atoms and a new carbon substituent. The utility of the methodology was demonstrated by preparing the stereotetrad of erythromycin in a short, efficient, and stereoselective route.