epi-5-(4-aminobutyl)-amino-1,3,2',6'-tetraazido neamine | 948916-02-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: epi-5-(4-aminobutyl)-amino-1,3,2',6'-tetraazido neamine
• CAS: 948916-02-7
• 化学式: C₁₆H₂₈N₁₄O₅
• 分子量: 496.489
• InChiKey: LOUNHLKOVGZSPC-CSYOCMBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.63
• 重原子数：
  35.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  312.24
• 氢给体数：
  5.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  epi-5-(4-aminobutyl)-amino-1,3,2',6'-tetraazido neamine 在 硫化氢 、 potassium carbonate 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 吡啶 、 甲醇 、 水 、 三乙胺 、 N,N-二甲基甲酰胺 为溶剂， 反应 23.0h， 生成
  参考文献：
  名称：

  Synthesis of aminodisaccharide–nucleoside conjugates for RNA binding

  摘要：

  Two types of aminodisaccharide-nucleoside conjugates were synthesized by the condensation of azidodisaccharide and nucleoside using aliphatic diamine as a linker. The corresponding azidodisaccharides could be yielded from neamine in good yield. The binding properties to 16S RNA of these conjugates were evaluated by SPR. It was found that the nucleobase played a significant role in the binding of these conjugates to 16S RNA and a shorter linker between the aminodisaccharide and nucleoside was favorable for 16S RNA binding. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.06.002
• 作为产物：
  描述：

  三氟甲磺酸酐 、 四亚甲基二胺 、 3',4',6-tri-O-acetyl-1,3,2',6'-tetrazidoneamine 以 吡啶 、 二氯甲烷 、 四氢呋喃 为溶剂， 反应 25.5h， 以57%的产率得到epi-5-(4-aminobutyl)-amino-1,3,2',6'-tetraazido neamine
  参考文献：
  名称：

  Synthesis of aminodisaccharide–nucleoside conjugates for RNA binding

  摘要：

  Two types of aminodisaccharide-nucleoside conjugates were synthesized by the condensation of azidodisaccharide and nucleoside using aliphatic diamine as a linker. The corresponding azidodisaccharides could be yielded from neamine in good yield. The binding properties to 16S RNA of these conjugates were evaluated by SPR. It was found that the nucleobase played a significant role in the binding of these conjugates to 16S RNA and a shorter linker between the aminodisaccharide and nucleoside was favorable for 16S RNA binding. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.06.002