4-Dimethylamino-α.α-bis-(2.6-dioxo-4.4-dimethyl-phenyl)-toluol | 33742-94-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-Dimethylamino-α.α-bis-(2.6-dioxo-4.4-dimethyl-phenyl)-toluol
• 英文别名: 5,5,5',5'-tetramethyl-2,2'-(4-dimethylamino-benzylidene)-bis-cyclohexane-1,3-dione；Bis-(2.6-dioxo-4.4-dimethyl-cycohexl)-(4-dimethylamino-phenyl)-methan；5,5,5',5'-Tetramethyl-2,2'-(4-dimethylamino-benzyliden)-bis-cyclohexan-1,3-dion；(4-Dimethylamino-benzyliden)-bis-dimethyldihydroresorcin；2-[[4-(Dimethylamino)phenyl](4,4-dimethyl-2,6-dioxocyclohexyl)methyl]-5,5-dimethyl-1,3-cyclohexanedione；2-[[4-(dimethylamino)phenyl]-(4,4-dimethyl-2,6-dioxocyclohexyl)methyl]-5,5-dimethylcyclohexane-1,3-dione
• CAS: 33742-94-8
• 化学式: C₂₅H₃₃NO₄
• 分子量: 411.541
• InChiKey: JVPRHRIFERQAJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  71.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-Dimethylamino-α.α-bis-(2.6-dioxo-4.4-dimethyl-phenyl)-toluol 在 甲酸 、 三乙胺 作用下， 生成 2-(4-dimethylamino-benzyl)-5,5-dimethyl-cyclohexane-1,3-dione
  参考文献：
  名称：

  Sekiya,M.; Suzuki,K., Chemical and pharmaceutical bulletin, 1971, vol. 19, p. 1540 - 1545

  摘要：

  DOI：
• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 生成 4-Dimethylamino-α.α-bis-(2.6-dioxo-4.4-dimethyl-phenyl)-toluol
  参考文献：
  名称：

  STRODS YA. A.; TSIEKURE V. P.; KAMPARS V. EH.; LIELBRIEDIS I. EH.; NEJLAN+, XIMIYA GETEROTSIKL. SOEDIN., 1978, HO 10, 1369-1372

  摘要：

  DOI：

文献信息

• A Green and Highly Efficient Protocol for Catalyst-free Knoevenagel Condensation and Michael Addition of Aromatic Aldehydes with 1,3-Cyclic Diketones in PEG-400
  作者：Nemati Firouzeh、Kiani Hossein

  DOI：10.1002/cjoc.201100005

  日期：2011.11

  A convenient, highly efficient and green approach for synthesis of tetraketones from aromatic aldehydes with dimedone and 1,3‐indanedione at room temperature in PEG‐400 is described. The use of PEG‐400 as the reaction medium and avoiding the use of any catalyst makes the process environmentally benign. Seven new compounds are reported.

  描述了一种在室温下PEG-400中由芳族醛与二甲酮和1,3-茚满二酮合成四酮的便捷，高效且绿色的方法。使用PEG-400作为反应介质并避免使用任何催化剂会使该过程对环境无害。据报道有七种新化合物。
• Vorlaender, Fresenius Zeitschrift fur Analytische Chemie, 1929, vol. 77, p. 266
  作者：Vorlaender

  DOI：——

  日期：——
• Desai; Wali, Journal of the Indian Chemical Society, 1936, vol. 13, p. 735,738
  作者：Desai、Wali

  DOI：——

  日期：——
• Tetraketones: A new class of tyrosinase inhibitors
  作者：Khalid Mohammed Khan、Ghulam Murtaza Maharvi、Mahmud Tareq Hassan Khan、Ahson Jabbar Shaikh、Shahnaz Perveen、Saeedan Begum、Mohammad Iqbal Choudhary

  DOI：10.1016/j.bmc.2005.08.029

  日期：2006.1

  Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC50 = 2.06 mu M), 11 (IC50 = 2.09 mu M), 15 (IC50 = 2.61 mu M), and 27 (IC50 = 3.19 mu M) were found to be the most active compounds of the series, even better than both standards kojic acid (IC50 = 16.67 mu M) and L-mimosine (IC50 = 3.68 mu M). This study may lead to the discovery of therapeutically potent agents against clinically very important dermatological disorders including hyperpigmentation as well as skin melanoma. (c) 2005 Elsevier Ltd. All rights reserved.
• METHONE DERIVATIVES OF ALDEHYDES
  作者：E. C. HORNING、M. G. HORNING

  DOI：10.1021/jo01171a014

  日期：1946.1