trichodermone | 2077-58-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: trichodermone
• 英文别名: Trichodermon；Dehydrororidin；(1R,2R,7R,9R)-1,2,5-trimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-11-one
• CAS: 2077-58-9
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: FEPADRJMTLDXMD-HHHGZCDHSA-N

物化性质

• 沸点：
  353.9±42.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  trichodermone 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以12 mg的产率得到9β,10β;12,13-diepoxytrichothecan-4-one
  参考文献：
  名称：

  Grove, John Frederick, Journal of the Chemical Society. Perkin transactions I, 1990, # 1, p. 115 - 122

  摘要：

  DOI：

文献信息

• RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS
  申请人：Steitz A. Thomas

  公开号：US20050036997A1

  公开（公告）日：2005-02-17

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  本发明提供了生产核糖体和核糖体亚基高分辨率晶体的方法，以及由这些方法产生的晶体。该发明还提供了核糖体亚基的高分辨率结构，无论是单独还是与蛋白质合成抑制剂结合。该发明提供了用于识别与核糖体相关的配体的方法，以及设计具有特定核糖体结合性质的配体的方法，以及可能起作用为蛋白质合成抑制剂的配体。因此，本发明的方法和组合物可用于生产专门设计用于杀灭或抑制任何目标生物生长的配体。
• Ribosome structure and protein synthesis inhibitors
  申请人：Steitz A. Thomas

  公开号：US20050272681A1

  公开（公告）日：2005-12-08

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  本发明提供了制备高分辨率核糖体和核糖体亚基晶体的方法，以及由这些方法产生的晶体。本发明还提供了核糖体亚基的高分辨率结构，无论是单独还是与蛋白质合成抑制剂结合。本发明提供了识别与核糖体相关的配体的方法，以及设计具有特定核糖体结合性质的配体的方法，以及可能作为蛋白质合成抑制剂的配体。因此，本发明的方法和组合物可用于生产旨在特异性杀死或抑制任何目标生物生长的配体。
• Ribosome Structure and Protein Synthesis Inhibitors
  申请人：Steitz Thomas

  公开号：US20100204253A1

  公开（公告）日：2010-08-12

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  该发明提供了制备高分辨率核糖体和核糖体亚基晶体的方法，以及由这些方法制备的晶体。该发明还提供了核糖体亚基的高分辨率结构，无论是单独还是与蛋白质合成抑制剂结合。该发明提供了识别与核糖体相关的配体的方法，以及设计具有特定核糖体结合性质的配体和可能作为蛋白质合成抑制剂的配体的方法。因此，该发明的方法和组合物可用于生产旨在特异性杀死或抑制任何目标生物生长的配体。
• High resolution crystal structure of the ribosome and design of protein synthesis inhibitors
  申请人：YALE UNIVERSITY

  公开号：EP1188769A2

  公开（公告）日：2002-03-20

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  本发明提供了生产核糖体和核糖体亚基高分辨率晶体的方法以及用这种方法生产的晶体。本发明还提供了核糖体亚基单独或与蛋白质合成抑制剂结合的高分辨率结构。本发明提供了鉴定核糖体相关配体的方法和设计具有特定核糖体结合特性的配体以及可作为蛋白质合成抑制剂的配体的方法。因此，本发明的方法和组合物可用来生产专门用于杀死或抑制任何目标生物生长的配体。
• Crystal structure of the large ribosomal subunit from S. aureus
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US10556934B2

  公开（公告）日：2020-02-11

  A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

  本文提供了一种包含病原菌大核糖体（50S）亚基结晶形式的物质组合物及其三维结构的原子坐标，以及结晶该物质组合物和利用该物质组合物的原子坐标设计对其具有高特异性的新配体的方法。