3-(2-{2-[2-(3-oxo-3-thiophen-2-yl-propenyl)-phenoxy]-ethoxy}-phenyl)-1-thiophen-2-yl-propenone | 889134-14-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(2-{2-[2-(3-oxo-3-thiophen-2-yl-propenyl)-phenoxy]-ethoxy}-phenyl)-1-thiophen-2-yl-propenone
• CAS: 889134-14-9
• 化学式: C₂₈H₂₂O₄S₂
• 分子量: 486.612
• InChiKey: OPRFAAYXRMBSOY-WXUKJITCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.06
• 重原子数：
  34.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  3-(2-{2-[2-(3-oxo-3-thiophen-2-yl-propenyl)-phenoxy]-ethoxy}-phenyl)-1-thiophen-2-yl-propenone 、 甲酸 在 一水合肼 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 以56%的产率得到
  参考文献：
  名称：

  Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties

  摘要：

  A variety of bis[3-aryl-4,5-dihydro-1H-pyrazol-1-carboxaldehydes] 4a-h were obtained via reaction of bis[1-aryl-2-propen-1-ones] 3a-h with hydrazine hydrate in refluxing formic acid. In addition, the corresponding bis[1-acetyl-3-aryl-4,5-dihydrol H-pyrazoles] 4i-m were formed through conducting the reaction of 3 with hydrazine hydrate in refluxing acetic acid. The starting bis(2-propen-1-ones) 3a-h were prepared stereoselectively as E,E'-geometric isomer via condensation of bisbenzaldehydes 1a,b with (un)substituted acetophetiones 2 in ethatiolic KOH solution. Anti-inflammatory as well as ulcerogenic activities of the prepared pyrazolines were evaluated in vivo and compared with that of a standard drug (indomethacin). Many of the tested compounds show remarkable anti-inflammatory properties with an ulcerogenic liability (especially 4f, g, j, and k) lower than that of the standard used drug. Compound 417 was established to be the best effectively prepared anti-inflammatory active pyrazoline derivative and safer than indomethacin with respect to its ulcerogenic liability. Molluscicidal activity of the prepared compounds against Biomphalaria alexandrina snails (the intermediate host of Schistosoma mansoni) was screened. Where, some of the prepared compounds show considerable activities. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.01.042
• 作为产物：
  描述：

  2-乙酰基噻吩 、 2-[2-(2-甲烷酰苯氧基)乙氧基]苯甲醛 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 48.0h， 以74%的产率得到3-(2-{2-[2-(3-oxo-3-thiophen-2-yl-propenyl)-phenoxy]-ethoxy}-phenyl)-1-thiophen-2-yl-propenone
  参考文献：
  名称：

  Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties

  摘要：

  A variety of bis[3-aryl-4,5-dihydro-1H-pyrazol-1-carboxaldehydes] 4a-h were obtained via reaction of bis[1-aryl-2-propen-1-ones] 3a-h with hydrazine hydrate in refluxing formic acid. In addition, the corresponding bis[1-acetyl-3-aryl-4,5-dihydrol H-pyrazoles] 4i-m were formed through conducting the reaction of 3 with hydrazine hydrate in refluxing acetic acid. The starting bis(2-propen-1-ones) 3a-h were prepared stereoselectively as E,E'-geometric isomer via condensation of bisbenzaldehydes 1a,b with (un)substituted acetophetiones 2 in ethatiolic KOH solution. Anti-inflammatory as well as ulcerogenic activities of the prepared pyrazolines were evaluated in vivo and compared with that of a standard drug (indomethacin). Many of the tested compounds show remarkable anti-inflammatory properties with an ulcerogenic liability (especially 4f, g, j, and k) lower than that of the standard used drug. Compound 417 was established to be the best effectively prepared anti-inflammatory active pyrazoline derivative and safer than indomethacin with respect to its ulcerogenic liability. Molluscicidal activity of the prepared compounds against Biomphalaria alexandrina snails (the intermediate host of Schistosoma mansoni) was screened. Where, some of the prepared compounds show considerable activities. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.01.042