4-(4-(2-(trimethylsilyl)ethylthio)phenoxy)pyridine | 1262327-69-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(4-(2-(trimethylsilyl)ethylthio)phenoxy)pyridine
• CAS: 1262327-69-4
• 化学式: C₁₆H₂₁NOSSi
• 分子量: 303.5
• InChiKey: VNDBPAPTMJGYFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  22.12
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-(4-(2-(trimethylsilyl)ethylthio)phenoxy)pyridine 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 生成 4-(Pyridin-4-yloxy)-benzenethiol
  参考文献：
  名称：

  Synthesis of dihydroindolizines for potential photoinduced work function alteration

  摘要：

  Seeking to immobilize photochromophores on metallic surfaces, we have synthesized four molecules which contain both a photoresponsive dihydroindolizine (DHI) core and a sulfur containing moiety, which allow for their assembly onto gold substrates. Sonogashira, Suzuki, or Ullmann couplings are employed to generate pyridines with pendant thioacetates (or disulfides). The pyridines are condensed with spiro[2-cyclopropene-1,9'[9H]fluorene]-2,3-dimethyl ester affording the targeted DHIs. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.097
• 作为产物：
  描述：

  4-氨基吡啶 在 copper(l) iodide 、 tetrafluoroboric acid 、 caesium carbonate 、 聚甘氨酸 、 sodium nitrite 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 生成 4-(4-(2-(trimethylsilyl)ethylthio)phenoxy)pyridine
  参考文献：
  名称：

  Synthesis of dihydroindolizines for potential photoinduced work function alteration

  摘要：

  Seeking to immobilize photochromophores on metallic surfaces, we have synthesized four molecules which contain both a photoresponsive dihydroindolizine (DHI) core and a sulfur containing moiety, which allow for their assembly onto gold substrates. Sonogashira, Suzuki, or Ullmann couplings are employed to generate pyridines with pendant thioacetates (or disulfides). The pyridines are condensed with spiro[2-cyclopropene-1,9'[9H]fluorene]-2,3-dimethyl ester affording the targeted DHIs. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.097