4-(2-Phenylquinolin-3-yl)benzaldehyde | 841303-93-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(2-Phenylquinolin-3-yl)benzaldehyde
• CAS: 841303-93-3
• 化学式: C₂₂H₁₅NO
• 分子量: 309.367
• InChiKey: FEHWVQLOLFXGEY-UHFFFAOYSA-N

物化性质

• 沸点：
  465.9±33.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-（2-酮酸-1-苯并咪唑）哌啶 、 4-(2-Phenylquinolin-3-yl)benzaldehyde 在 MP-BH₃(CN) 作用下， 以94%的产率得到1-(1-{[4-(2-phenylquinolin-3-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
  参考文献：
  名称：

  Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

  摘要：

  This letter describes the discovery of a novel series of dual Akt1/Akt2 kinase inhibitors, based on a 2,3,5-trisubstituted pyridine scaffold. Compounds from this series, which contain a 5-tetrazolyl moiety, exhibit more potent inhibition of Akt2 than Akt1. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.062
• 作为产物：
  描述：

  2-苯基喹啉-3-醇 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 caesium carbonate 作用下， 以 四氢呋喃 、 吡啶 、 水 为溶剂， 反应 0.17h， 生成 4-(2-Phenylquinolin-3-yl)benzaldehyde
  参考文献：
  名称：

  Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

  摘要：

  This letter describes the discovery of a novel series of dual Akt1/Akt2 kinase inhibitors, based on a 2,3,5-trisubstituted pyridine scaffold. Compounds from this series, which contain a 5-tetrazolyl moiety, exhibit more potent inhibition of Akt2 than Akt1. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.062

文献信息

• US7223738B2
  申请人：——

  公开号：US7223738B2

  公开（公告）日：2007-05-29
• Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
  作者：Zhijian Zhao、William H. Leister、Ronald G. Robinson、Stanley F. Barnett、Deborah Defeo-Jones、Raymond E. Jones、George D. Hartman、Joel R. Huff、Hans E. Huber、Mark E. Duggan、Craig W. Lindsley

  DOI：10.1016/j.bmcl.2004.12.062

  日期：2005.2

  This letter describes the discovery of a novel series of dual Akt1/Akt2 kinase inhibitors, based on a 2,3,5-trisubstituted pyridine scaffold. Compounds from this series, which contain a 5-tetrazolyl moiety, exhibit more potent inhibition of Akt2 than Akt1. (C) 2005 Elsevier Ltd. All rights reserved.