4-甲氧基-2-甲酰基苯硼酸 | 139962-95-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-甲氧基-2-甲酰基苯硼酸
• 中文别名: (2-甲酰基-4-甲氧苯基)硼酸；2-醛基-4-甲氧基苯硼酸
• 英文名称: 2-formyl-4-methoxyphenylboronic acid
• 英文别名: 4-methoxy-2-formylphenylboronic acid；2-formyl-4-methoxybenzeneboronic acid；2-(dihydroxyboryl)-5-methoxybenzaldehyde；(2-formyl-4-methoxyphenyl)boronic acid
• CAS: 139962-95-1
• 化学式: C₈H₉BO₄
• mdl: MFCD01319043
• 分子量: 179.968
• InChiKey: ZSSNGMFKYFBOAG-UHFFFAOYSA-N

物化性质

• 熔点：
  166-170 °C
• 沸点：
  395.2±52.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)
• 溶解度：
  溶于甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  1.06
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT, KEEP COLD
• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• 安全说明：
  S26,S37/39
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  0-6°C

SDS

Name:	4-Methoxy-2-Formylphenylboronic Acid Material Safety Data Sheet
Synonym:	None Known
CAS:	139962-95-1

Section 1 - Chemical Product MSDS Name:4-Methoxy-2-Formylphenylboronic Acid Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
139962-95-1	4-Methoxy-2-Formylphenylboronic Acid	ca. 100	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4C/39F.)

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 139962-95-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H9BO4
Molecular Weight: 179.96

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, acids, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, boron oxides.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 139962-95-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-Methoxy-2-Formylphenylboronic Acid - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 139962-95-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 139962-95-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 139962-95-1 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-甲氧基-2-甲酰基苯硼酸 在 bis-triphenylphosphine-palladium(II) chloride 、 sulfonamide 、 水 、 potassium carbonate 、 caesium carbonate 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N-二异丙基乙胺 、 三氟乙酸 、 lithium hydroxide 作用下， 以 四氢呋喃 、 二恶烷 、 甲醇 、 乙二醇二甲醚 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 2,19-methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione, 27-cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-, 10,10-dioxide
  参考文献：
  名称：

  Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

  摘要：

  Optimization of a novel series of macrocyclic indole-based inhibitors of the HCV NS5b polymerase targeting the finger loop domain led to the discovery of lead compounds exhibiting improved potency in cellular assays and superior pharmacokinetic profile. Further lead optimization performed on the most promising unsaturated-bridged subseries provided the clinical candidate 27-cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-10,10-dioxide-2,19-methano-3,7: 4,1-dimetheno-1H, 11H-14,10,2,9,11,17-benzoxathiatetraazacyclo docosine-8,18(9H, 15H)-dione, TMC647055 (compound 18a). This non-zwitterionic 17-membered ring macrocycle combines nanomolar cellular potency (EC50 of 82 nM) with minimal associated cell toxicity (CC50 >20 mu M) and promising pharmacokinetic profiles in rats and dogs. TMC647055 is currently being evaluated in the clinic. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.113
• 作为产物：
  描述：

  2-溴-5-甲氧基苯甲醛 在 正丁基锂 作用下， 以 四氢呋喃 、 二氯甲烷 、 环己烷 为溶剂， 反应 2.5h， 生成 4-甲氧基-2-甲酰基苯硼酸
  参考文献：
  名称：

  可持续的 Passerini-四唑三组分反应 (PT-3CR)：选择性合成氧杂四唑

  摘要：

  首次开发了一种可持续的无催化剂和无溶剂 Passerini-四唑三组分反应 (PT-3CR)，用于选择性合成苯并恶硼醇-四唑。oxaboroles 的合成潜力在各种官能化四唑方面得到了证明，否则很难通过传统的 PT-3CR 从芳香醛/酮中实现。该反应具有实用性高、底物范围广、产率高（80-98%）等特点。不对称 PT-3CR 的初步结果也显示为手性苯并氧杂硼的合成。

  DOI：

  10.1039/d1cc03256a
• 作为试剂：
  描述：

  4-甲氧基-2-甲酰基苯硼酸 、 2-bromo-3-cyclohexyl-N-[(dimethylamino)sulfonyl]-1H-indole-6-carboxamide 在 4-甲氧基-2-甲酰基苯硼酸 作用下， 以87的产率得到6H-Isoindolo[2,1-a]indole-3-carboxamide, 11-cyclohexyl-N-[(dimethylamino)sulfonyl]-6-ethoxy-8-methoxy-
  参考文献：
  名称：

  [EN] VIRAL POLYMERASE INHIBITORS
  [FR] INHIBITEURS DE POLYMERASE VIRALE

  摘要：

  化合物的同分异构体、对映异构体、顺反异构体或互变异构体，由式(I)表示：其中A、B、R2、R3、L、M1、M2、M3、M4、Y1、Y0、Z和Sp如权利要求1中所定义，或其盐，作为HCV NS5B聚合酶的抑制剂。

  公开号：

  WO2004065367A1

文献信息

• Synthesis, Characterisation, and Antifungal Activities of Novel Benzodiazaborines
  作者：Jiyoung Yang、Brandon J. Johnson、Allan A. Letourneau、Christopher M. Vogels、Andreas Decken、Felix J. Baerlocher、Stephen A. Westcott

  DOI：10.1071/ch14534

  日期：——

  Eight new fluoro- and methoxy-substituted benzodiazaborines have been prepared by a simple condensation reaction in high-to-excellent yields. All new compounds have been characterised by several physical methods, including X-ray diffraction studies on three examples. All new compounds were examined for antifungal activities against five species of potentially pathogenic fungi (Aspergillus niger, Aspergillus fumigatus, Rhizoctonia solani, Verticillium albo-atrum, and Verticillium dahliae). While substitution of the aromatic group derived from the 2-formylphenylboronic acid group had an effect on bioactivities, substitution on the parent thioamide C(=S)NH2 group of the starting thiosemicarbazide greatly reduced activities.

  通过简单的缩合反应，我们制备出了八种新的氟代和甲氧基代苯并二氮硼烷，而且产量极高。所有新化合物都通过多种物理方法进行了表征，包括对三个实例进行了 X 射线衍射研究。所有新化合物都对五种潜在致病真菌（黑曲霉、烟曲霉、根瘤菌、轮枝菌和大丽花轮枝菌）进行了抗真菌活性检测。虽然 2-甲酰基苯硼酸基团衍生的芳香基团的取代对生物活性有影响，但起始硫代氨基甲酰肼的母硫酰胺 C(=S)NH2 基团的取代却大大降低了活性。
• [EN] AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF<br/>[FR] AZAINDAZOLES COMME MODULATEURS DE LA KINASE BTK ET LEUR UTILISATION
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2011019780A1

  公开（公告）日：2011-02-17

  Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, (I) are useful as kinase modulators, including Btk modulation, wherein A1, A2, A3, R4, are as defined herein.

  具有化学式(I)的化合物，以及其对映体、非对映异构体、药用可接受的盐，(I)可用作激酶调节剂，包括Btk调节，在此处定义了A1、A2、A3、R4。
• Palladium-catalyzed Suzuki–Miyaura coupling of amides by carbon–nitrogen cleavage: general strategy for amide N–C bond activation
  作者：Guangrong Meng、Michal Szostak

  DOI：10.1039/c6ob00084c

  日期：——

  limitations are presented in the synthesis of >60 functionalized ketones. Mechanistic studies provide insight into the catalytic cycle of the cross-coupling, including the first experimental evidence for Pd insertion into the amide N–C bond. The synthetic utility is showcased by a gram-scale cross-coupling and cross-coupling at room temperature. Most importantly, this process provides a blueprint for the

  据报道，第一个钯催化的Suzuki-Miyaura酰胺与硼酸的交叉偶联通过空间控制的NC键活化来合成酮。该转化的特点是使用稳定的市售试剂和催化剂可简化操作，并具有广泛的底物范围，包括在两个偶合配偶体，位阻，杂环，卤化物，酯和酮上均具有供电子和吸电子基团的底物。范围和局限性在> 60种功能化的酮的合成中给出。机理研究为交叉偶联的催化循环提供了见识，其中包括将Pd插入酰胺N-C键的第一个实验证据。克级交叉耦合和室温下的交叉耦合展示了合成实用程序。最重要的是，通过酰基金属中间体。概述了激活酰胺键以使金属插入到N–C酰胺键中的统一策略（方案1）。
• Intramolecular carbonyl-ene reactions in the synthesis of peri-oxygenated hydroaromatics
  作者：Shyam Basak、Dipakranjan Mal

  DOI：10.1016/j.tet.2016.02.033

  日期：2016.4

  Suzuki coupling of 2-formylphenylboronic acids, are shown to provide cycloalkylidene ene products under acidic conditions. Susceptibility of the products to aromatization is manoeuvred by varying the reaction conditions and catalysts including binol-derived Brønsted acid catalysts. A peri-effect is identified as a controlling factor for the aromatizations. Several oxidative transformations of an ene product

  通过2-甲酰基苯基硼酸的Suzuki偶联合成的2-甲基烯丙基芳族醛显示在酸性条件下提供环亚烷基烯产物。通过改变反应条件和催化剂，包括由二元醇衍生的布朗斯台德酸催化剂，可以控制产品对芳构化的敏感性。一围-效应被确定为芳构化控制因素。烯产物的几种氧化转化作为氢化芳族聚酮化合物天然产物的模型研究而进行。
• Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress
  作者：Qin Wang、Katherine J. Franz

  DOI：10.1016/j.bmc.2018.11.004

  日期：2018.12

  BSIH ((E)-N′-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylidene)isonicotinohydrazide) is a prodrug version of the metal chelator SIH ((E)-N′-(2-hydroxybenzylidene)isonicotinohydrazide) in which a boronate group prevents metal chelation until reaction with hydrogen peroxide releases SIH, which is then available for sequestering iron(III) and inhibiting iron-catalyzed oxidative damage. While BSIH

  BSIH（（（E）-N '-（2-（4,4,5,5-tetramethyl-1,3,2-dioxaboroboro-2--2-yl）苄叉基）异烟肼）是金属螯合剂SIH（（E）-N'-（2-羟基亚苄基）异二十二酰肼）中的硼酸酯基团防止金属螯合，直到与过氧化氢反应释放出SIH，然后可用于螯合铁（III）和抑制铁催化的氧化损伤。虽然BSIH已显示出在氧化应激条件下有条件地靶向细胞螯合铁的前景，但由于BSIH以其水解产物异烟肼和2-甲酰基苯基硼酸作为平衡混合物存在于细胞培养基中的事实限制了SIH的产量。在当前的研究中，评估了几种BSIH类似物的水解稳定性，与H 2 O 2的反应结果以及螯合剂到螯合剂的转化效率。值得注意的是，对甲氧基衍生物（p-OMe）BSIH（（E）-N '-（5-甲氧基-2-（4,4,5,5-四甲基-1,3,2-二氧杂硼烷-2-基）亚苄基）异烟肼基）和间位- ，第-double取代的（MD）BSIH（（ë）